Ignet

Gene Information

Gene symbol: PLG

Gene name: plasminogen

HGNC ID: 9071

Related Genes

#	Gene Symbol	Number of hits
1	APP	1 hits
2	CAP1	1 hits
3	COL1A1	1 hits
4	CRP	1 hits
5	F12	1 hits
6	FLT4	1 hits
7	GAPDH	1 hits
8	HABP2	1 hits
9	KNG1	1 hits
10	NRSN1	1 hits
11	PLAT	1 hits
12	ZMPSTE24	1 hits

Related Sentences

#	PMID	Sentence
1	7327427	Toxic granulomas produced by metals may be caused by C3 being split by plasmin after conversion from plasminogen by activation of the Hageman factor.
2	10699327	In contrast to the observations with gp120, immunization in baboons with PLG/p24 in MF59 induced significantly enhanced antibody responses after boosting, in comparison to immunization with MF59 alone + p24.
3	11578745	Vmd ranged from 87-128 to 42-157 microm for PLG and PCL, respectively.
4	11578745	There was no detectable cleavage of the protein during 6 months storage of PLG and PCL microcapsules at 4 degrees C.
5	11578745	Vmd ranged from 87-128 to 42-157 microm for PLG and PCL, respectively.
6	11578745	There was no detectable cleavage of the protein during 6 months storage of PLG and PCL microcapsules at 4 degrees C.
7	14550583	Genes with codons optimized for mammalian expression were synthesized for the SIVmac239 Gag, a secreted SIV Gag protein with the tissue plasminogen antigen (tPA) signal fused to its N-terminus (tPA/Gag), as well as their corresponding chimeric proteins Gag/LLO and tPA/Gag/LLO containing the C-terminal 59 amino acids of LLO.
8	14550583	Analysis of immune responses to these DNA constructs in a Balb/c mouse model showed that the Gag/LLO construct induced higher levels of both CD4 and CD8 T cell responses against SIV Gag, whereas the tPA/Gag construct induced higher levels of CD4 T cell responses.
9	14550583	Moreover, immunization with the tPA/Gag/LLO construct further enhanced both CD4 and CD8 T cell responses.
10	15955451	The recombinantly expressed protein shows GAPDH enzymatic activity as well as plasminogen-binding capacity.
11	16153533	The hyaluronan-binding protease upregulates ERK1/2 and PI3K/Akt signalling pathways in fibroblasts and stimulates cell proliferation and migration.
12	16153533	The hyaluronan-binding protease (HABP) is a serine protease in human plasma which is structurally related to plasminogen activators, coagulation factor XII and hepathocyte growth factor activator.
13	16153533	It can in vitro activate the coagulation factor FVII, kininogen and plasminogen activators.
14	16153533	Treatment of lung fibroblasts with HABP lead to a rapid activation of signalling pathways, including the mitogen-activated protein kinase (MAPK) pathway with c-Raf, MEK and ERK1/2.
15	16153533	Additionally the activation of the PI3K/Akt pathway and of several translation-related proteins was found.
16	16153533	Stimulation of signalling and proliferation by HABP involved the fibroblast growth factor receptor 1 (FGFR-1).
17	16153533	HABP-stimulated proliferation of lung fibroblasts MRC-5 was accompanied by a significant intracellular increase in basic fibroblast growth factor (bFGF), the major ligand of FGFR-1; bFGF could however not be identified in the supernatant of HABP-treated cells.
18	16153533	The hyaluronan-binding protease upregulates ERK1/2 and PI3K/Akt signalling pathways in fibroblasts and stimulates cell proliferation and migration.
19	16153533	The hyaluronan-binding protease (HABP) is a serine protease in human plasma which is structurally related to plasminogen activators, coagulation factor XII and hepathocyte growth factor activator.
20	16153533	It can in vitro activate the coagulation factor FVII, kininogen and plasminogen activators.
21	16153533	Treatment of lung fibroblasts with HABP lead to a rapid activation of signalling pathways, including the mitogen-activated protein kinase (MAPK) pathway with c-Raf, MEK and ERK1/2.
22	16153533	Additionally the activation of the PI3K/Akt pathway and of several translation-related proteins was found.
23	16153533	Stimulation of signalling and proliferation by HABP involved the fibroblast growth factor receptor 1 (FGFR-1).
24	16153533	HABP-stimulated proliferation of lung fibroblasts MRC-5 was accompanied by a significant intracellular increase in basic fibroblast growth factor (bFGF), the major ligand of FGFR-1; bFGF could however not be identified in the supernatant of HABP-treated cells.
25	16154491	In order to investigate whether DC properties are influenced by proteins present in the plasma, we matured human monocyte-derived DC with four main plasma components: fibrinogen, fibronectin, plasminogen or C-reactive protein.
26	16154491	These purified proteins were added at various concentrations on day 6 after the initial differentiation induced by IL-4 and GM-CSF.
27	16154491	The maturation was assessed by phenotyping of maturation-associated marker (CD83) and co-stimulatory molecule CD86 as well as IL-12 production.
28	16972797	HABP cleaves kininogen in vitro, releasing the vasoactive peptide bradykinin, and activates plasminogen activators, suggesting a vascular cell-directed physiological function of this novel plasma protease.
29	16972797	On the one hand, HABP releases bradykinin from cell surface-bound or soluble kininogen and triggers a bradykinin B2-receptor-dependent mobilisation of intracellular Ca2+.
30	16972797	On the other hand, HABP activates the p44/42-dependent MAPK (ERK1/2) signalling cascade independent of the B2-receptor, but involving the fibroblast growth factor receptor-1 and basic fibroblast growth factor.
31	16972797	This signalling pathway leads to phosphorylation of the kinases Raf, MEK1/2 and ERK1/2.
32	16972797	The extracellular activity of HABP also affects the gene expression level through phosphorylation of two transcription factors, the cAMP-responsive element binding protein CREB and the proto-oncogene c-Myc.
33	18162266	The combination of alum, MF59, CAP or PLG with CpG generally induced slightly more potent titres.
34	18980172	Preparation, physiochemical characterization, and oral immunogenicity of Abeta(1-12), Abeta(29-40), and Abeta(1-42) loaded PLG microparticles formulations.
35	18980172	The prepared Abeta PLG microparticles were smooth, spherical, individual, and nonporous in nature with diameters ranging from 2 to 12 microm.
36	18980172	The cumulative in vitro release profiles of Abeta(1-12), Abeta(29-40), and Abeta(1-42) from PLG microparticles sustained for long periods and progressively reached to 73.89%, 69.29%, and 70.08% by week 15.
37	18980172	Preparation, physiochemical characterization, and oral immunogenicity of Abeta(1-12), Abeta(29-40), and Abeta(1-42) loaded PLG microparticles formulations.
38	18980172	The prepared Abeta PLG microparticles were smooth, spherical, individual, and nonporous in nature with diameters ranging from 2 to 12 microm.
39	18980172	The cumulative in vitro release profiles of Abeta(1-12), Abeta(29-40), and Abeta(1-42) from PLG microparticles sustained for long periods and progressively reached to 73.89%, 69.29%, and 70.08% by week 15.
40	18980172	Preparation, physiochemical characterization, and oral immunogenicity of Abeta(1-12), Abeta(29-40), and Abeta(1-42) loaded PLG microparticles formulations.
41	18980172	The prepared Abeta PLG microparticles were smooth, spherical, individual, and nonporous in nature with diameters ranging from 2 to 12 microm.
42	18980172	The cumulative in vitro release profiles of Abeta(1-12), Abeta(29-40), and Abeta(1-42) from PLG microparticles sustained for long periods and progressively reached to 73.89%, 69.29%, and 70.08% by week 15.
43	25409527	This study showed a marked ability of MntC to bind to several ECM and coagulation cascade components, including laminin, collagen type IV, cellular and plasma fibronectin, plasminogen and fibrinogen by ELISA.
44	26396191	To this aim, we evaluated sera from children with IPD and age-matched controls against 141 20-mer synthetic peptides covering the entire sequence of major antigenic fragments within pneumococcal virulence proteins; namely, choline-binding protein D (CbpD), pneumococcal histidine triad proteins (PhtD and PhtE), pneumococcal surface protein A (PspA), plasminogen and fibronectin binding protein B (PfbB), and zinc metalloproteinase B (ZmpB).