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Gene Information
Gene symbol: PLK1
Gene name: polo-like kinase 1
HGNC ID: 9077
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AURKA | 1 hits |
| 2 | BIRC5 | 1 hits |
| 3 | CDC2 | 1 hits |
| 4 | FOXM1 | 1 hits |
| 5 | MAP2K3 | 1 hits |
| 6 | NEK2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20023695 | The Ras oncogene is known to activate three major MAPK pathways, ERK, JNK, p38 and exert distinct cellular phenotypes, that is, apoptosis and invasion through the Ras-MKK3-p38-signaling cascade. |
| 2 | 20023695 | Stable transfection of NIH3T3 fibroblasts with MKK3(act) cDNA construct revealed similar p38-dependent in vitro characteristics observed in Ha-Ras(EJ)-transformed NIH3T3 cells, including enhanced invasiveness and anchorage-independent growth correlating with p38 phosphorylation status. |
| 3 | 20023695 | Using this phenotype-assisted approach combined with system level protein-interaction network analysis, we identified FOXM1, PLK1 and CDK1 to be differentially regulated in invasive Ha-Ras(EJ)-NIH3T3 and MKK3(act)-NIH3T3 cells. |
| 4 | 22001602 | In this study, we compared the efficiencies of G2/M-related antigens including Birc5, Aurka, Nke2 and Plk1 by using a DNA vaccination model. |
| 5 | 22001602 | It was found that Birc5 and Aurka are expressed in both CSCs/CICs and non-CSCs/CICs (shared antigens), whereas Nek2 and Plk1 are expressed preferentially in non-CSCs/CICs (non-CSC antigens). |
| 6 | 22001602 | Furthermore, we established a heat shock protein (Hsp90)-fused Birc5 plasmid to improve anti-cancer immunity. |
| 7 | 22001602 | Birc5 fused to the N-terminal region of Hsp90 showed a stronger anti-tumor effect, whereas Birc5 fused to the C-terminal region of Hsp90 did not show enhancement compared with Birc5. |