Ignet

Gene Information

Gene symbol: POLD4

Gene name: polymerase (DNA-directed), delta 4, accessory subunit

HGNC ID: 14106

Synonyms: p12, POLDS

Related Genes

#	Gene Symbol	Number of hits
1	ACRV1	1 hits
2	AHSA1	1 hits
3	BUD31	1 hits
4	CALR	1 hits
5	CD4	1 hits
6	CD8A	1 hits
7	CDKN2A	1 hits
8	DCTN5	1 hits
9	EXOSC1	1 hits
10	EXOSC3	1 hits
11	HBZ	1 hits
12	HLA-A	1 hits
13	IFNG	1 hits
14	IL2	1 hits
15	IL2RA	1 hits
16	MAPT	1 hits
17	MRPL28	1 hits
18	NRSN1	1 hits
19	PRR6	1 hits
20	PSMD9	1 hits
21	TLR3	1 hits
22	TLR4	1 hits
23	TLR7	1 hits

Related Sentences

#	PMID	Sentence
1	1765564	Assignment of the gene for human intra-acrosomal protein SP-10 to the p12----q13 region of chromosome 11.
2	1765564	The hybrid XER-7 with the 11/X translocation: 11p12 or 11p11----11qter:: Xq11----Xqter and the hybrid EXR-5CSAZ with the X/11 translocation: Xpter----Xq22::11q13----11qter localized the SP-10 gene to the p12----q13 region.
3	1765564	Assignment of the gene for human intra-acrosomal protein SP-10 to the p12----q13 region of chromosome 11.
4	1765564	The hybrid XER-7 with the 11/X translocation: 11p12 or 11p11----11qter:: Xq11----Xqter and the hybrid EXR-5CSAZ with the X/11 translocation: Xpter----Xq22::11q13----11qter localized the SP-10 gene to the p12----q13 region.
5	2560858	By WB and competitive WB assays, bovine sera that were ELISA-positive to BLV reacted with one or more of p12, p15, and p24 of BLV, and with only p24 of HTLV-I.
6	2560858	Human sera that were ELISA-positive to HTLV-I reacted with p12 and p24 of BLV, and with one or more of p12, p15, p19, and p24 of HTLV-I.
7	2560858	By WB and competitive WB assays, bovine sera that were ELISA-positive to BLV reacted with one or more of p12, p15, and p24 of BLV, and with only p24 of HTLV-I.
8	2560858	Human sera that were ELISA-positive to HTLV-I reacted with p12 and p24 of BLV, and with one or more of p12, p15, p19, and p24 of HTLV-I.
9	3008410	Western blot analysis identifies FeLV-gp70, p27, p15, p12, and p10 in the subunit vaccine preparation.
10	7972096	In addition to these activators, the bovine leukemia virus (BLV) and the human T-cell leukemia virus (HTLV) contain alternative open reading frames (R3 and G4 for BLV; p30, p13, and p12 for HTLV).
11	9272702	A 25-mer polypeptide (P12-25) encoded within the gag p12 region of the MAIDS defective virus was found to be effective in stimulating unprimed B6 (H-2b) CD8+ T cells in vitro.
12	10936091	One of these viral proteins, p12(I), encoded by HTLV-I orfI, is a weak oncogene that binds the 16-kDa subunit of the vacuolar ATPase and interacts with the immature beta and gamma(c) chains of the IL-2 receptor.
13	12050010	A peptide derived from ZF1 had a higher quantum yield and longer average lifetime (tau) than ZF2.
14	12050010	BLV p12 tau and rotational correlation time were greater than ZF values, but all de-metallated sequences gave similar results.
15	12654813	Testing of antigen-specific CD4(+) T-cell lines with the individual peptides of MPB70 confirmed that peptides p8, p12, and p13 contain immunodominant Th1 cell epitopes of MPB70.
16	12654813	The T-cell lines responding to MPB70 and peptides p8, p12, and p13 in IFN-gamma assays mediated antigen-peptide-specific cytotoxic activity against monocytes/macrophages pulsed with the whole-protein antigen or the peptides.
17	12654813	Testing of antigen-specific CD4(+) T-cell lines with the individual peptides of MPB70 confirmed that peptides p8, p12, and p13 contain immunodominant Th1 cell epitopes of MPB70.
18	12654813	The T-cell lines responding to MPB70 and peptides p8, p12, and p13 in IFN-gamma assays mediated antigen-peptide-specific cytotoxic activity against monocytes/macrophages pulsed with the whole-protein antigen or the peptides.
19	16492399	The LLR strain is a G10 P12 type, which is in use as a licensed human vaccine in China.
20	18791162	The uncleaved 12-kDa form of p12(I) resides in the ER and interacts with the beta and gamma(c) chains of the interleukin-2 receptor (IL-2R), the heavy chain of the major histocompatibility complex (MHC) class I, as well as calreticulin and calnexin.
21	20647569	Requirement of the human T-cell leukemia virus p12 and p30 products for infectivity of human dendritic cells and macaques but not rabbits.
22	20647569	We demonstrate that ablation of the HTLV-1 genes encoding p12, p30, or the HBZ protein, does not affect viral infectivity in rabbits and in this species, only the absence of HBZ is associated with a consistent reduction in virus levels.
23	20647569	Interestingly, we found that the p12 and the p30 mutants were also severely impaired in their ability to replicate in human dendritic cells.
24	20647569	Requirement of the human T-cell leukemia virus p12 and p30 products for infectivity of human dendritic cells and macaques but not rabbits.
25	20647569	We demonstrate that ablation of the HTLV-1 genes encoding p12, p30, or the HBZ protein, does not affect viral infectivity in rabbits and in this species, only the absence of HBZ is associated with a consistent reduction in virus levels.
26	20647569	Interestingly, we found that the p12 and the p30 mutants were also severely impaired in their ability to replicate in human dendritic cells.
27	20647569	Requirement of the human T-cell leukemia virus p12 and p30 products for infectivity of human dendritic cells and macaques but not rabbits.
28	20647569	We demonstrate that ablation of the HTLV-1 genes encoding p12, p30, or the HBZ protein, does not affect viral infectivity in rabbits and in this species, only the absence of HBZ is associated with a consistent reduction in virus levels.
29	20647569	Interestingly, we found that the p12 and the p30 mutants were also severely impaired in their ability to replicate in human dendritic cells.
30	21528538	To investigate the genetic stability (including the vector of vaccinia virus and six foreign genes: gp160, gag, pol, rev, tat and nef) of the HIV-1 non-replicating recombinant vaccinia virus (rNTV-C). rNTV-C was serially passaged to passage 25 (P25) in primary chicken embryo fibroblast (CEF).
31	21528538	P9, P12, P15 and P25 were selected to study the genetic stability in four aspects, including the genetic stability of viral vector, the genetic stability of six foreign genes, the expressing stability of foreign genes and the genetic loss of foreign genes.
32	21994758	Singly spliced mRNA from orf-I encodes p12, which can be proteolytically cleaved to generate p8, while differential splicing of mRNA from orf-II results in production of p13 and p30.
33	21994758	Though these proteins are not essential for virus replication in vitro, p8, p12, p13, and p30 have an important role in the establishment and maintenance of HTLV-1 infection in vivo.
34	24155397	Human T-cell leukemia/lymphoma virus type 1 p30, but not p12/p8, counteracts toll-like receptor 3 (TLR3) and TLR4 signaling in human monocytes and dendritic cells.
35	24155397	We used a human monocytic cell line, THP-1, and dendritic cells to study the mechanism of p30 and p12/p8 requirements in these cell types. p30 inhibited the expression of interferon (IFN)-responsive genes (ISG) following stimulation by lipopolysaccharide (LPS) of Toll-like receptor 4 (TLR4) and by poly(I·C) of TLR3 but not of TLR7/8 with imiquimod.
36	24155397	HTLV-1 infection of monocytes inhibited TLR3- and TLR4-induced ISG expression by 50 to 90% depending on the genes, whereas the isogenic clone p30 knockout virus was less effective at inhibiting TLR3 and TRL4 signaling and displayed lower infectivity.
37	24155397	A chromatin immunoprecipitation assay demonstrated that p30 inhibits initiation and elongation of PU.1-dependent transcription of IFN-α1, IFN-β, and TLR4 genes upon TLR stimulation.
38	24533461	Low genetic diversity and functional constraint in loci encoding Plasmodium vivax P12 and P38 proteins in the Colombian population.