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Gene Information
Gene symbol: PPA1
Gene name: pyrophosphatase (inorganic) 1
HGNC ID: 9226
Synonyms: SID6-8061, Ppase, IOPPP, PP1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ENPP1 | 1 hits |
| 2 | GMPS | 1 hits |
| 3 | NPY6R | 1 hits |
| 4 | PDIA3 | 1 hits |
| 5 | PLCB4 | 1 hits |
| 6 | PPP1CA | 1 hits |
| 7 | PRKCA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17562331 | In this study, we demonstrated that the phosphoinositide-phospholipase C (PI-PLC) downstream signaling pathway is involved in M. bovis BCG-induced CXCL8 release, since A549 cells pretreated with U73122, a PI-PLC inhibitor, inhibited CXCL8 release, whereas U73343 the inactive analog had no effect. |
| 2 | 17562331 | In addition, our results demonstrated that M. bovis BCG-induced CXCL8 production by A549 cells was significantly blocked by using neomycin (another well-described inhibitor of PI-PLC with a different mechanism of action), Ro-32-0432 and Ro-31-8220 (two PKCalpha inhibitors), PP1 and PP2 (two potent and selective inhibitors of the Src-family tyrosine kinases), and Bay 11-7082 (an IkappaB phosphorylation inhibitor). |
| 3 | 17562331 | We also demonstrated that M. bovis BCG can rapidly induce translocation of PKCalpha from the cytosol to the membrane, and that treatment of cells with M. bovis BCG caused time-dependent increases in phosphorylation of c-Src at tyrosine 416. |
| 4 | 17562331 | Finally, our studies revealed that M. bovis BCG induced the association of c-Src and IKKalphabeta during the interaction of PKCalpha and IKKalphabeta. |
| 5 | 17562331 | Altogether, these results represent the first evidence to date suggesting that M. bovis BCG activates the PI-PLC/PKCalpha/c-Src/IKKalphabeta signaling pathway to induce CXCL8 release in human epithelial cells. |
| 6 | 22119138 | The activity of ATP pyrophosphatase domain is independent of glutamine amidotransferase domain, whereas the latter cannot catalyze hydrolysis of glutamine to NH(3) and glutamate in the absence of substrates. |
| 7 | 23169635 | Here we show that these classic functions of B-1a cells segregate between two unique subsets defined by expression of plasma cell alloantigen 1 (PC1), also known as ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1). |
| 8 | 26026715 | To better understand the role of serine/threonine protein phosphatase 1 (PP1) in reproductive processes of male adult T. canis, differential expression analysis was used to reveal the profiles of PP1 catalytic subunit α (PP1cα) gene Tc-stp-1 and PP1 regulatory subunit 7 (PP1r7) gene TcM-1309. |