- About
- Home
- Introduction
- Statistics
- Programs
- Dignet
- Gene
- GenePair
- BioSummarAI
- Help & Docs
- Documents
- Help
- FAQs
- Links
- Acknowledge
- Disclaimer
- Contact Us
Gene Information
Gene symbol: PPIA
Gene name: peptidylprolyl isomerase A (cyclophilin A)
HGNC ID: 9253
Synonyms: CYPA
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD4 | 1 hits |
| 2 | FKBP1A | 1 hits |
| 3 | FKBP1B | 1 hits |
| 4 | HSPA1A | 1 hits |
| 5 | HSPB1 | 1 hits |
| 6 | IRF3 | 1 hits |
| 7 | PPIB | 1 hits |
| 8 | PPIH | 1 hits |
| 9 | SELENBP1 | 1 hits |
| 10 | SH2D3A | 1 hits |
| 11 | TFP | 1 hits |
| 12 | TRIM39 | 1 hits |
| 13 | TRIM5 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 9465090 | Taken together with our observations that recombinant CyPA-induced mobilization of calcium in immortalized, as well as primary, CD4+ T lymphocytes, and that incubation of T cells with iodinated CyPA, followed by chemical cross-linking, resulted in the formation of a high molecular mass complex on the cell surface, these results suggest that HIV-1-associated CyPA mediates an early event in viral infection via interaction with a cellular receptor. |
| 2 | 10231014 | Co-immunoprecipitation and Western blot studies show that hsp27, hsp70, and hsp78 complex with HIV-1 viral proteins intracellularly. |
| 3 | 10231014 | Hsp70, hsp56, and CypA are assembled into HIV-1 virions. |
| 4 | 11727548 | Cumulative findings are cited implicating CypA, Hsp27, Hsp70 and FKBPs in host cell and viral activation, viral entry, assembly or formation of infectious virions. |
| 5 | 20829794 | This innate response is dependent on the interaction of newly synthesized HIV-1 capsid with cellular cyclophilin A (CYPA) and the subsequent activation of the transcription factor IRF3. |
| 6 | 21734037 | Animals coexpressing the TRIM5(TFP) and TRIM5(CypA) alleles took significantly longer to become infected with SIVsmE660, but not SIVmac239, after repeated limiting-dose intrarectal challenge than did animals expressing other TRIM5 allele combinations. |
| 7 | 21929574 | The rhesus macaque TRIM5 gene has been shown to display polymorphism, with different variants being divided into three groups (TRIM5(TFP), TRIM5(Q), and TRIM5(CypA)), which may have divergent retroviral effects on infection. |
| 8 | 21929574 | We demonstrate the presence of the TRIM5(TFP) group in cynomolgus macaques. |
| 9 | 22046132 | In this study, we used a systems biology approach employing a genome-wide yeast-two hybrid interaction screen to identify immunopilins (PPIA, PPIB, PPIH, PPIG, FKBP1A, FKBP1B) as interaction partners of the CoV non-structural protein 1 (Nsp1). |
| 10 | 22046132 | Overexpression of NSP1 and infection with live SARS-CoV strongly increased signalling through the Calcineurin/NFAT pathway and enhanced the induction of interleukin 2, compatible with late-stage immunopathogenicity and long-term cytokine dysregulation as observed in severe SARS cases. |