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Gene Information
Gene symbol: PPP1R15A
Gene name: protein phosphatase 1, regulatory subunit 15A
HGNC ID: 14375
Synonyms: GADD34
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BAX | 1 hits |
| 2 | BCL2 | 1 hits |
| 3 | CASP3 | 1 hits |
| 4 | GLI2 | 1 hits |
| 5 | HSPA5 | 1 hits |
| 6 | IL24 | 1 hits |
| 7 | MCL1 | 1 hits |
| 8 | PEG3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19075917 | Some of the patents and patent applications discuss newly discovered tumor suppressor genes, including WW Domain-Containing Oxidoreductase (WWOX), Cancer Associated Ring-1 (CAR-1), Human Cervical Cancer Suppressor 1 (HCCS-1), Src-suppressed C kinase substrate (SSeCKS), ADP-Ribosylation factor-like putative Tumor Suppressor gene 1 (ARTS1), and Deleted in Osteosarcoma (DOS). |
| 2 | 19075917 | Another patent application recently published describes a chimeric tumor suppressor gene generated by combining a portion of the rat PEG-3 protein with the human GADD34 protein, thus creating a protein with apoptotic activity. |
| 3 | 26225923 | Interleukin-24 (IL-24), a member of the IL-10 cytokine gene family, causes growth suppression and apoptosis in various solid tumor cells. |
| 4 | 26225923 | In addition, IL-24 expression could significantly induce apoptosis of the THP-1 cells. |
| 5 | 26225923 | Ad.RGD-IL-24 had a potent effect on the up-regulation of the expression of GRP78/Bip, GADD34 and Bax, down-regulation of the expression of Bcl-2 and Mcl-1, and induced the activation of Caspase-3, which may be responsible for its apoptosis-inducing effect on THP-1 cells. |