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Gene Information
Gene symbol: PPP2R4
Gene name: protein phosphatase 2A activator, regulatory subunit 4
HGNC ID: 9308
Synonyms: PTPA, PR53
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IRF3 | 1 hits |
| 2 | PPP5C | 1 hits |
| 3 | RRM1 | 1 hits |
| 4 | TBK1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12880984 | First, after immunoprecipitation of MHC class I from NXS2 cells, peptides were eluted and examined in tandem-MS analysis which lead to the identification of three novel natural MHC class I peptide ligands, TEALPVKLI from ribonucleotide reductase M2, NEYIMSLI from Ser/Thr protein phosphatase 2A and FEMVSTLI with unknown origin. |
| 2 | 15650237 | This led to the identification of three novel natural MHC class I peptide ligands: TEALPVKLI, from ribonucleotide reductase M2; NEYIMSLI, from Ser/Thr protein phosphatase 2A; and FEMVSTLI, of unknown origin. |
| 3 | 20558243 | Intranasal immunization was assayed in C57BL/6 mice against Angiostrongylus costaricensis using a synthetic and a recombinant peptide belonging to the catalytic region of the serine/threonine phosphatase 2 A (PP2A) of the parasite. |
| 4 | 20558243 | A significant increase in IFN gamma and IL-17 levels was observed in the group with 100% protection. |
| 5 | 25810395 | Casein kinase II controls TBK1/IRF3 activation in IFN response against viral infection. |
| 6 | 25810395 | In this study, we report that protein kinase CK2 serves as a key component controlling TBK1 and IRF3 activation in IFN-inducing TLR, RIG-I-like receptors, and cGAS/STING signaling pathways. |
| 7 | 25810395 | Moreover, PP2A was identified as one of the intermediate phosphatases responsible for CK2-regulated IFN response, suggesting that CK2 may regulate TBK1 and IRF3 activation indirectly. |
| 8 | 25810395 | Taken together, our results identify CK2 as a novel regulator of TBK1 and IRF3 and suggest that targeting CK2 by small molecular inhibitor may be a viable approach to prevent and treat viral infections. |