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Gene Information
Gene symbol: PRF1
Gene name: perforin 1 (pore forming protein)
HGNC ID: 9360
Synonyms: PFP, P1, HPLH2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCR5 | 1 hits |
| 2 | CD27 | 1 hits |
| 3 | CD8A | 1 hits |
| 4 | CXCR3 | 1 hits |
| 5 | EOMES | 1 hits |
| 6 | GZMA | 1 hits |
| 7 | GZMB | 1 hits |
| 8 | IFNG | 1 hits |
| 9 | IL7R | 1 hits |
| 10 | KLRD1 | 1 hits |
| 11 | RARB | 1 hits |
| 12 | XCL1 | 1 hits |
| 13 | ZNF395 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20739541 | The vac+ variants were distinguished from the vac- variants on the basis of their content of viral subpopulations by (i) the capacity to induce higher quantum yields of interferon (IFN), (ii) the generation of an unusual type of IFN-induction dose-response curve, (iii) the presence of IFPs that induce IFN more efficiently, (iv) reduced sensitivity to IFN action, and (v) elevated rates of PFP replication that resulted in larger plaques and higher PFP and HAP titers. |
| 2 | 22735807 | We have previously shown that vaccination with the natural tumor peptide Melan-A-induced T cells with superior effector functions as compared with vaccination with the analog peptide optimized for enhanced HLA-A*0201 binding. |
| 3 | 22735807 | Here we found that natural peptide vaccination induced tumor-reactive CD8 T cells with frequent coexpression of both memory/homing-associated genes (CD27, IL7R, EOMES, CXCR3, and CCR5) and effector-related genes (IFNG, KLRD1, PRF1, and GZMB), comparable with protective Epstein-Barr virus-specific and cytomegalovirus-specific T cells. |
| 4 | 25597949 | Short exposure to AFB1 suppressed innate immune transcripts, especially from antimicrobial genes, but increased the expression of transcripts from E3 ubiquitin-protein ligase CBL-B and multiple interleukin-2 response genes. |
| 5 | 25597949 | Up-regulation of transcripts from lymphotactin, granzyme A, and perforin 1 could indicate either increased cytotoxic potential or activation-induced cell death in the spleen during aflatoxicosis. |