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Gene Information
Gene symbol: PRKAA1
Gene name: protein kinase, AMP-activated, alpha 1 catalytic subunit
HGNC ID: 9376
Synonyms: AMPKa1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD8A | 1 hits |
| 2 | HMGB1 | 1 hits |
| 3 | INS | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21810053 | We then review the experimental data on investigational immunomodulatory agents targeting the host inflammatory response in severe influenza, including anti-TNF therapy, statins, glucocorticoids, cyclooxygenase-2 inhibitors, macrolides, peroxisome proliferator-activated receptor agonists, AMP-activated protein kinase agonists and high mobility group box 1 antagonists. |
| 2 | 25624476 | In addition, it increased the number of CD8(+) tumor-infiltrating lymphocytes (TILs) and protected them from apoptosis and exhaustion characterized by decreased production of IL-2, TNFα, and IFNγ. |
| 3 | 25624476 | CD8(+) TILs capable of producing multiple cytokines were mainly PD-1(-)Tim-3(+), an effector memory subset responsible for tumor rejection. |
| 4 | 25624476 | Combined use of metformin and cancer vaccine improved CD8(+) TIL multifunctionality. |
| 5 | 25624476 | The adoptive transfer of antigen-specific CD8(+) T cells treated with metformin concentrations as low as 10 μM showed efficient migration into tumors while maintaining multifunctionality in a manner sensitive to the AMP-activated protein kinase (AMPK) inhibitor compound C. |
| 6 | 26162543 | Rhizoma Anemarrhenae extract ameliorates hyperglycemia and insulin resistance via activation of AMP-activated protein kinase in diabetic rodents. |