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Gene Information

Gene symbol: PRKCQ

Gene name: protein kinase C, theta

HGNC ID: 9410

Related Genes

#	Gene Symbol	Number of hits
1	CD28	1 hits
2	IL2	1 hits
3	NFKB1	1 hits
4	PIK3CA	1 hits

Related Sentences

#	PMID	Sentence
1	15585831	Cutting edge: CD28-mediated transcriptional and posttranscriptional regulation of IL-2 expression are controlled through different signaling pathways.
2	15585831	PI3K was identified early as a candidate for CD28 signaling, but conflicting data during the past decade has left the role of PI3K unresolved.
3	15585831	We show that mutation of the PI3K interaction site in the cytosolic tail of CD28 site disrupts the ability of CD28 to recruit protein kinase C-theta; to the central supramolecular activation cluster (c-SMAC) region of the immunological synapse, promote NF-kappaB nuclear translocation, and enhance IL-2 gene transcription.
4	15585831	In contrast, mutation of the PI3K interaction site had no effect on the ability of CD28 to enhance IL-2 mRNA stability.
5	15585831	These results suggest that two distinct pathways mediate CD28-induced up-regulation of IL-2 expression, a PI3K-dependent pathway that may function through the immunological synapse to enhance IL-2 transcription and a PI3K-independent pathway that induces IL-2 mRNA stability.
6	19017952	During T cell interaction with APC, CD28 is recruited to the central region (cSMAC) of the immunological synapse.
7	19017952	CD28-mediated signaling through PI3K results in the recruitment of protein kinase C-theta (PKCtheta) to the cSMAC, activation of NF-kappaB, and up-regulation of IL-2 transcription.
8	19017952	In this report, we show that CD28 recruitment and persistence at the immunological synapse requires TCR signals and CD80 engagement.
9	19017952	Addition of mAb to either MHC class II or CD80 results in the rapid displacement of CD28 from the immunological synapse.
10	19017952	Ligand binding is not sufficient for CD28 localization to the immunological synapse, as truncation of the cytosolic tail of CD28 disrupts synapse localization without effecting the ability of CD28 to bind CD80.
11	19017952	Mutation of tyrosine 188 also results in diminished activation of NF-kappaB, suggesting that CD28-mediated localization of PKCtheta to the cSMAC is important for efficient signal transduction.