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Gene Information
Gene symbol: PSENEN
Gene name: presenilin enhancer 2 homolog (C. elegans)
HGNC ID: 30100
Synonyms: PEN2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BACE1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12491772 | Recently, PS1 and PS2 are shown to be the catalytic subunits of gamma-secretase that cleaves the intramembrane segments of beta APP and Notch. beta-amyloid hypothesis that emphasizes the primacy of A beta in the pathogenesis of AD is currently being verified by the new experimental therapeutic approaches, e.g., A beta vaccine therapy or administration of inhibitors of beta- or gamma-secretases. |
| 2 | 12491772 | The mechanistic roles of newly identified co-factor proteins of PS (i.e., APH-1 and PEN-2) in gamma-secretase function, as well as recent advances in the development of gamma- or beta-secretase inhibitors will be discussed. |