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Gene Information
Gene symbol: PSME1
Gene name: proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
HGNC ID: 9568
Synonyms: IFI5111, PA28alpha
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | PSMB10 | 1 hits |
| 2 | PSMB8 | 1 hits |
| 3 | PSMB9 | 1 hits |
| 4 | PSME2 | 1 hits |
| 5 | PSME3 | 1 hits |
| 6 | SEC14L2 | 1 hits |
| 7 | TAP2 | 1 hits |
| 8 | TAPBP | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11162627 | Using the reverse transcription PCR, we evaluated expression levels of various antigen presentation-related genes, including LMP2, LMP7, MECL-1, PA28alpha, PA28beta, TAP1, TAP2, and tapasin, in two oral squamous cell carcinoma cell lines, HSC5 and HSC7. |
| 2 | 11162627 | Expression levels of LMP2, MECL-1, TAP1, and TAP2 transcripts are reduced in both cell lines in comparison with a normal epithelial cell line. |
| 3 | 11162627 | Further, HSC5 and HSC7 show diminished expression of LMP7/tapasin, and PA28alpha/beta, respectively. |
| 4 | 11162627 | Surface expression of HLA-B alleles is down-regulated in both lines presumably due to low expression of TAP1/2. |
| 5 | 11162627 | Using the reverse transcription PCR, we evaluated expression levels of various antigen presentation-related genes, including LMP2, LMP7, MECL-1, PA28alpha, PA28beta, TAP1, TAP2, and tapasin, in two oral squamous cell carcinoma cell lines, HSC5 and HSC7. |
| 6 | 11162627 | Expression levels of LMP2, MECL-1, TAP1, and TAP2 transcripts are reduced in both cell lines in comparison with a normal epithelial cell line. |
| 7 | 11162627 | Further, HSC5 and HSC7 show diminished expression of LMP7/tapasin, and PA28alpha/beta, respectively. |
| 8 | 11162627 | Surface expression of HLA-B alleles is down-regulated in both lines presumably due to low expression of TAP1/2. |
| 9 | 11739503 | The proteasome regulator PA28alpha/beta was up-regulated, whereas PA28gamma was reduced in the liver of lymphocytic choriomeningitis virus-infected mice. |
| 10 | 16515877 | The ubiquitin-proteasome system (UPS) plays an indispensable role in inducing MHC class I-restricted CD8+ T cells and was exploited in the development of a DNA vaccine against the intracellular protozoan Toxoplasma gondii by constructing a chimeric DNA encoding a fusion protein between murine ubiquitin and the toxoplasma antigen SAG1. |
| 11 | 16515877 | Mice vaccinated with the DNA acquired potent protective immunity mediated by MHC class I-restricted CD8+ T cells against infection by the highly virulent Toxoplasma. |
| 12 | 16515877 | The accelerated degradation and induction of immunity were dependent on the UPS since mice lacking an immuno-subunit of 20S proteasome, LMP7, lost these functions, although they were independent of the proteasome regulator PA28alpha/beta complex. |
| 13 | 18321749 | Here, to develop a vaccine strategy taking advantage of activated CD8(+)T cells, we constructed a DNA vaccine, designated pGFP-TSA1, encoding a fusion protein linking GFP to a single CTL epitope of TSA1, a leading candidate for vaccine against T. cruzi. |
| 14 | 18321749 | Vaccination with pGFP-TSA1 enhanced epitope-specific cytotoxicity and IFN-gamma secretion by CD8(+)T cells. |
| 15 | 18321749 | When mice deficient in the proteasome activator PA28alpha/beta or the immunoproteasome subunits LMP2 and LMP7 were used, the protective immunity against infection was profoundly attenuated. |
| 16 | 18321749 | Our findings clearly demonstrate that vaccination with pGFP-TSA1 successfully induces protection dependent on CD8(+)T cell activation, in which immunoproteasomes play a crucial role. |