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Gene Information
Gene symbol: PTAFR
Gene name: platelet-activating factor receptor
HGNC ID: 9582
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IL8 | 1 hits |
| 2 | LTA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20826612 | The concentrations of several chemoattractants for neutrophils (CXCL1, CXCL2, CXCL3, CXCL8, and C5a) increased in milk after challenge, and the highest increases followed challenge with the combination of MDP and LTA. |
| 2 | 20826612 | Nucleotide-binding oligomerization domain 2 (NOD2), a major sensor of MDP, was expressed (mRNA) in bovine mammary tissue and by bMEpC in culture. |
| 3 | 20826612 | The production of interleukin-8 (IL-8) following the stimulation of bMEpC by LTA and MDP was dependent on the activation of NF-κB. |
| 4 | 20826612 | LTA-induced IL-8 production did not depend on platelet-activating factor receptor (PAFR), as the PAFR antagonist WEB2086 was without effect. |
| 5 | 20826612 | Although the levels of expression of the inflammatory cytokines tumor necrosis factor alpha (TNF-α) and IL-1β were increased by LTA and MDP at the mRNA level, no protein could be detected in the bMEpC culture supernatant. |
| 6 | 20826612 | Overall, this study indicates that the TLR2 and NOD2 pathways could cooperate to trigger an innate immune response to S. aureus mastitis. |