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Gene Information
Gene symbol: PTGES
Gene name: prostaglandin E synthase
HGNC ID: 9599
Synonyms: MGST-IV, PIG12, MGST1-L1, TP53I12
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | PTGS1 | 1 hits |
| 2 | PTGS2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16204627 | Splenic PGE2-M Ø from Balb/c mice, given 0.01 or 1 mg heat-killed (HK) Mycobacterium bovis bacillus Calmette-Guerin (BCG) intraperitoneally (i.p.), were characterized by the ex vivo release of PGE2 (>10 ng/10(6) cells), cytokine production, and expression of PGG/H synthase (PGHS)-1, PGHS-2, cytosolic PGE synthase (PGES), and microsomal PGES-1. |
| 2 | 16204627 | At Day 14 after the treatment, mice treated with 1 mg, but not 0.01 mg, BCG had increased levels of PGHS-2+ PGE2-MØ, total serum immunoglobulin E (IgE), and serum IgG1 antibodies (Th2 responses) against heat shock protein 65 and purified protein derivative. |
| 3 | 16204627 | Cultures of spleen cells isolated from these mice expressed interleukin (IL)-4 and IL-10 in recall responses. |
| 4 | 16204627 | Treatment of mice receiving 1 mg BCG with NS-398 (a PGHS-2 inhibitor, 10 mg/kg i.p., daily) resulted in enhanced interferon-gamma (IFN-gamma) production with reduced IL-4 and IL-10 production in recall responses. |
| 5 | 16204627 | Treatment of C57Bl/6 mice with HK-BCG (0.5 mg dose) also induced a mixture of Th1 and Th2 responses, although IFN-gamma production was markedly increased, and IL-4 was decreased compared with Balb/c mice. |