Ignet

Gene Information

Gene symbol: PVRL1

Gene name: poliovirus receptor-related 1 (herpesvirus entry mediator C)

HGNC ID: 9706

Synonyms: PRR, PRR1, PVRR1, SK-12, HIgR, CLPED1, CD111, OFC7

Related Genes

#	Gene Symbol	Number of hits
1	ADAR	1 hits
2	BTN2A1	1 hits
3	BTN3A3	1 hits
4	CD14	1 hits
5	DARC	1 hits
6	IL10RB	1 hits
7	LY96	1 hits
8	MX1	1 hits
9	NLRP3	1 hits
10	PVR	1 hits
11	PVRL2	1 hits
12	PVRL3	1 hits
13	PVRL4	1 hits
14	TLR2	1 hits
15	TLR4	1 hits
16	TNF	1 hits
17	TNFRSF14	1 hits
18	TRIM22	1 hits
19	YME1L1	1 hits
20	ZFP57	1 hits

Related Sentences

#	PMID	Sentence
1	15273289	These receptors include the herpesvirus entry mediator (HVEM), nectin-1, nectin-2, and sites in heparan sulfate generated by specific 3-O-sulfotransferases.
2	15273289	The objective of the present study was to identify residues in gD that are critical for physical and functional interactions with nectin-1 and nectin-2.
3	15273289	We found that double or triple amino acid substitutions at positions 215, 222, and 223 in gD caused marked reduction in gD binding to nectin-1 and a corresponding inability to function in cell fusion or entry of HSV via nectin-1 or nectin-2.
4	15273289	These receptors include the herpesvirus entry mediator (HVEM), nectin-1, nectin-2, and sites in heparan sulfate generated by specific 3-O-sulfotransferases.
5	15273289	The objective of the present study was to identify residues in gD that are critical for physical and functional interactions with nectin-1 and nectin-2.
6	15273289	We found that double or triple amino acid substitutions at positions 215, 222, and 223 in gD caused marked reduction in gD binding to nectin-1 and a corresponding inability to function in cell fusion or entry of HSV via nectin-1 or nectin-2.
7	15273289	These receptors include the herpesvirus entry mediator (HVEM), nectin-1, nectin-2, and sites in heparan sulfate generated by specific 3-O-sulfotransferases.
8	15273289	The objective of the present study was to identify residues in gD that are critical for physical and functional interactions with nectin-1 and nectin-2.
9	15273289	We found that double or triple amino acid substitutions at positions 215, 222, and 223 in gD caused marked reduction in gD binding to nectin-1 and a corresponding inability to function in cell fusion or entry of HSV via nectin-1 or nectin-2.
10	16426010	We recently demonstrated that the pattern recognition receptors (PRRs) toll-like receptor 2 (TLR2), TLR4, and CD14 are expressed in mouse colonic epithelium in a compartmentalized manner.
11	16426010	Interestingly, while TLR2, TLR4, and CD14 were up-regulated in the inflamed colon, TLR5 was down-regulated at both the mRNA and protein levels.
12	16426010	Additional in vitro studies using a mouse cell line, Colon-26, showed that gamma interferon (IFN-gamma) time- and dose-dependently down-regulates TLR5.
13	16426010	TLR5 expression is down-regulated in vivo during acute and chronic DSS-induced colitis, in contrast to the expression of TLR2, TLR4, and CD14.
14	16426010	Finally, IFN-gamma may be involved in down-regulating TLR5 expression.
15	16427216	Nectin-1, also known as herpesvirus entry mediator C (HveC), is an alphaherpesvirus receptor that binds to virion glycoprotein D (gD).
16	18243431	HSV-1 glycoprotein D (gD) interacts with HVEM and nectin-1 cell receptors to initiate virus entry.
17	18243431	These mutations were constructed with the intent of evaluating infection in vivo when virus enters by HVEM but not nectin-1 receptors and were based on prior reports demonstrating that purified gDA3C/Y38C protein binds to HVEM but not to nectin-1.
18	18243431	The resultant HSV-1 strain, KOS-gDA3C, had a single amino acid mutation at residue 3 and exhibited reduced entry into both HVEM and nectin-1 expressing cells.
19	18243431	HSV-1 glycoprotein D (gD) interacts with HVEM and nectin-1 cell receptors to initiate virus entry.
20	18243431	These mutations were constructed with the intent of evaluating infection in vivo when virus enters by HVEM but not nectin-1 receptors and were based on prior reports demonstrating that purified gDA3C/Y38C protein binds to HVEM but not to nectin-1.
21	18243431	The resultant HSV-1 strain, KOS-gDA3C, had a single amino acid mutation at residue 3 and exhibited reduced entry into both HVEM and nectin-1 expressing cells.
22	18243431	HSV-1 glycoprotein D (gD) interacts with HVEM and nectin-1 cell receptors to initiate virus entry.
23	18243431	These mutations were constructed with the intent of evaluating infection in vivo when virus enters by HVEM but not nectin-1 receptors and were based on prior reports demonstrating that purified gDA3C/Y38C protein binds to HVEM but not to nectin-1.
24	18243431	The resultant HSV-1 strain, KOS-gDA3C, had a single amino acid mutation at residue 3 and exhibited reduced entry into both HVEM and nectin-1 expressing cells.
25	18606550	It has been found that the PRR bind unit structures of PAMP, and that PAMP-binding involves several other humoral and cell membrane proteins, exemplified by the more or less simultaneous LPS recognition displayed by MD-2, CD-14 and TLR4 on the cell membrane.
26	18606550	In turn, this may activate Th1 and Th2 immune responses with production of Th1 or Th2 signature molecules such as IFN-gamma and IL-4, respectively [2-4].
27	19339346	HSV infection of both CD4(+) and CD8(+) T cells occurred much more efficiently via direct cell-to-cell spread from infected fibroblasts than by cell-free virus.
28	19339346	Transfer of HSV to T cells required gD, and the four known entry receptors appear to be contributing to viral entry, with a dominant role for the herpesvirus entry mediator and nectin-1.
29	19428913	It has recently been shown that one member of an intracellular PRR, the NLRP3 inflammasome, is activated by a number of classical adjuvants including aluminum hydroxide and saponins [Eisenbarth SC, Colegio OR, O'Connor W, Sutterwala FS, Flavell RA.
30	19428913	In comparison, NLRP3-deficient and caspase-1-deficient macrophages showed negligible production of IL-1beta.
31	20054979	The interactions are complex and are yet to be translated into a clear understanding of the roles of the respective PAMPs and PRRs in vivo.
32	21560483	Increasing numbers of endogenous danger signals of host origin are being identified including, for example, uric acid and cholesterol crystals, high mobility group box1 (HMGB1) protein, oxidized LDL, vesicans, heat shock proteins (HSPs) and self DNA.
33	21560483	Moreover, some PRRs (e.g., TLR2,TLR4 and NLRP3) and atypical PRRs can recognize both PAMPs and DAMPs, either as single entities or after forming complexes (e.g., immune complexes, or DNA- HMGB1 and DNA-LL37 complexes), so there must be a mechanism to selectively depress or alleviate the inflammatory response to DAMPs, while leaving that of PAMPs intact.
34	21560483	For example, CD24 reacting with HMGB1 and HSPs has been implicated to function as negative regulator for RAGE.
35	22993162	We used the HSV-2 BAC clone to construct an HSV-2 glycoprotein D mutant (HSV2-gD27) with point mutations in amino acids 215, 222, and 223, which are critical for the interaction of gD with nectin-1.
36	23771216	Wild-type measles virus infection upregulates poliovirus receptor-related 4 and causes apoptosis in brain endothelial cells by induction of tumor necrosis factor-related apoptosis-inducing ligand.
37	23771216	Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), but not Fas ligand, was induced by MV infection.
38	26329766	Of these SNPs, we detected eight in the PVRL3 gene, five in the PVRL1 gene, one in the TRIM22 gene, two in the IL10RB gene, two in the TLR4 gene, and five in other genes (PVR, ADAR, ZFP57, MX1, and BTN2A1/BTN3A3).