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Gene Information
Gene symbol: RAC2
Gene name: ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
HGNC ID: 9802
Synonyms: EN-7
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | CORO1A | 1 hits |
| 3 | GNAI2 | 1 hits |
| 4 | MAPK1 | 1 hits |
| 5 | MNDA | 1 hits |
| 6 | PIK3CA | 1 hits |
| 7 | S100A8 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 26275051 | The microarray analyses of the CD34+ cells and granulocytes were performed from 20 de novo MPN subjects: JAK2 positive ET, PV, PMF subjects, and JAK2 negative ET/PMF subjects. |
| 2 | 26275051 | Thirty-six genes (including RUNX1, TNFRSF19) were persistently highly expressed, while 42 genes (including FOXD4, PDE4A) were underexpressed both in CD34+ cells and granulocytes. |
| 3 | 26275051 | Using proteomic studies, significant up-regulation was observed for MAPK and PI3K/AKT signaling regulators that control myeloid cell apoptosis and proliferation: RAC2, MNDA, S100A8/9, CORO1A, and GNAI2. |
| 4 | 26275051 | When the status of the mTOR signaling pathway related genes was analyzed, PI3K/AKT regulators were preferentially up-regulated in CD34+ cells of MPNs, with down-regulated major components of the protein complex EIF4F. |
| 5 | 26275051 | Molecular profiling of CD34+ cells and granulocytes of MPN determined gene expression patterns beyond their recognized function in disease pathogenesis that included dominant up-regulation of PI3K/AKT signaling. |