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Gene Information
Gene symbol: RHOBTB2
Gene name: Rho-related BTB domain containing 2
HGNC ID: 18756
Synonyms: KIAA0717, DBC2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BCL2 | 1 hits |
| 2 | CCDC25 | 1 hits |
| 3 | CDKN1A | 1 hits |
| 4 | MYC | 1 hits |
| 5 | PTK2B | 1 hits |
| 6 | SCARA3 | 1 hits |
| 7 | TNFRSF10D | 1 hits |
| 8 | TP53 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 26378933 | In vitro analysis revealed a higher resistance to bortezomib possibly due to an altered gene expression profile caused by del(8)(p21) including genes such as TRAIL-R4, CCDC25, RHOBTB2, PTK2B, SCARA3, MYC, BCL2 and TP53. |
| 2 | 26378933 | Furthermore, while bortezomib sensitized MM cells without del(8)(p21) to TRAIL/APO2L mediated apoptosis, in cells with del(8)(p21) bortezomib failed to upregulate the pro-apoptotic death receptors TRAIL-R1 and TRAIL-R2 which are located on the 8p21 region. |
| 3 | 26378933 | Also expressing higher levels of the decoy death receptor TRAIL-R4, these cells were largely resistant to TRAIL/APO2L mediated apoptosis. |