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Gene Information
Gene symbol: RPA1
Gene name: replication protein A1, 70kDa
HGNC ID: 10289
Synonyms: REPA1, RPA70, HSSB, RF-A, RP-A
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD80 | 1 hits |
| 2 | CD86 | 1 hits |
| 3 | CDK5RAP2 | 1 hits |
| 4 | ICAM1 | 1 hits |
| 5 | NT5C2 | 1 hits |
| 6 | PTH | 1 hits |
| 7 | PTHLH | 1 hits |
| 8 | TXN | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11597390 | An engineered plasmid (GC90) expressing the parathyroid hormone-related peptide (PTH-rP), a protein secreted by prostate and lung carcinoma cells, was included in influenza virosomes (GC90V). |
| 2 | 12391194 | High-affinity HLA-A(*)02.01 peptides from parathyroid hormone-related protein generate in vitro and in vivo antitumor CTL response without autoimmune side effects. |
| 3 | 12391194 | Parathyroid hormone-related protein (PTH-rP), a protein produced by prostate carcinoma and other epithelial cancers, is a key agent in the development of bone metastases. |
| 4 | 12391194 | We investigated whether the protein follows the self-tolerance paradigm or can be used as a target Ag for anticancer immunotherapy by investigating the immunogenicity of two HLA-A(*)02.01-binding PTH-rP-derived peptides (PTR-2 and -4) with different affinity qualities. |
| 5 | 12391194 | PTH-rP peptide-specific CTL lines were generated from the PBMC of two HLA-A(*)02.01(+) healthy individuals, stimulated in vitro with PTH-rP peptide-loaded autologous dendritic cells and IL-2. |
| 6 | 12838324 | Parathyroid hormone-related protein (PTH-rP), a secreted protein produced by prostate carcinoma and other epithelial cancers, is considered a key agent for the development of bone metastases. |
| 7 | 12838324 | We investigated the construct GC90/IRIV, composed of immunopotentiating reconstituted influenza virosomes (IRIV) containing PTH-rP gene plasmids (GC90), as a potential tool for human anticancer immunotherapy into humanised mice transgenic for HLA-A(*)02.01, the human-beta2 microglobulin, and the human CD8alpha molecule. |
| 8 | 15893625 | As compared with soluble rPA, it was found that coculture of DC with rPA-loaded microparticles stimulated higher levels of MHC II, CD54, CD80 and CD86 expression (p<0.05). |
| 9 | 16519970 | Additional purification of GMP rPA by anion exchange chromatography separated and enriched the two principal isoforms. |
| 10 | 16519970 | There was no significant difference in the biological activity of each isoform compared to GMP rPA when analyzed in the presence of lethal factor using a macrophage lysis assay. |
| 11 | 16519970 | Additional purification of GMP rPA by anion exchange chromatography separated and enriched the two principal isoforms. |
| 12 | 16519970 | There was no significant difference in the biological activity of each isoform compared to GMP rPA when analyzed in the presence of lethal factor using a macrophage lysis assay. |
| 13 | 19464533 | Mice were vaccinated in the ear pinnae with rPA or rPA+C48/80, CpG oligodeoxynucleotides (CpG), or cholera toxin (CT). |
| 14 | 23880942 | As a result, the fully soluble rPA and PA4 proteins were successfully expressed in Escherichia coli by co-expression with thioredoxin (Trx), and the rPA was active in forming cytotoxic lethal toxins, indicating that the rPA protein retains a functionally biological activity. |