Ignet

Gene Information

Gene symbol: RRM1

Gene name: ribonucleotide reductase M1

HGNC ID: 10451

Related Genes

#	Gene Symbol	Number of hits
1	BRCA1	1 hits
2	C1orf107	1 hits
3	CASP8	1 hits
4	CD40	1 hits
5	CD8A	1 hits
6	DTYMK	1 hits
7	DUSP11	1 hits
8	DUT	1 hits
9	ERCC1	1 hits
10	HIST3H2A	1 hits
11	HIST3H3	1 hits
12	HLA-A	1 hits
13	IL10	1 hits
14	OBP2A	1 hits
15	OLFM4	1 hits
16	PPP2R4	1 hits
17	RPS27A	1 hits
18	TXN	1 hits
19	TYMS	1 hits

Related Sentences

#	PMID	Sentence
1	9010995	The repertoire is now growing rapidly and includes 7 additional glycoproteins (gE, gI, gH, gL, gG, gK and gM), a number of enzymes (e.g. ribonucleotide reductase, DNA Polymerase, dUTPase), and a group of regulatory proteins (BICPO, 4, 22, and 27, alpha TIF).
2	10774198	The products of the virulent genes of herpes simplex virus, described in this paper, are enzymes (thymidine kinase, ribonucleotide reductase, deoxyuridine triphosphatase, DNA polymerase, and two protein kinases), glycoproteins (gC, gE), immediate early gene product (ICP47) and gamma 34.5.
3	12880984	First, after immunoprecipitation of MHC class I from NXS2 cells, peptides were eluted and examined in tandem-MS analysis which lead to the identification of three novel natural MHC class I peptide ligands, TEALPVKLI from ribonucleotide reductase M2, NEYIMSLI from Ser/Thr protein phosphatase 2A and FEMVSTLI with unknown origin.
4	14658844	Sections from the cultured TG fragments were stained with antisera against non-structural proteins such as the immediate early (IE) protein ICP27 and the early (E) proteins thymidine kinase (TK), the large subunit of ribonucleotide reductase (RR1), the ori-binding protein OBP and with a human serum obtained from volunteers immunized with an experimental subunit HSV-1 envelope (env) vaccine containing late structural proteins gB1, gC1, gD1 and gG1 (env antiserum).
5	14658844	The RR1 and OBP antisera stained productively infected Vero cells from 3 and 4 hrs post inoculation (p.i.), respectively.
6	14658844	Sections from the cultured TG fragments were stained with antisera against non-structural proteins such as the immediate early (IE) protein ICP27 and the early (E) proteins thymidine kinase (TK), the large subunit of ribonucleotide reductase (RR1), the ori-binding protein OBP and with a human serum obtained from volunteers immunized with an experimental subunit HSV-1 envelope (env) vaccine containing late structural proteins gB1, gC1, gD1 and gG1 (env antiserum).
7	14658844	The RR1 and OBP antisera stained productively infected Vero cells from 3 and 4 hrs post inoculation (p.i.), respectively.
8	14671117	Divergent regions contain gene families, which overall comprise over 49% of the CNPV genome and include genes encoding 51 proteins containing ankyrin repeats, 26 N1R/p28-like proteins, and potential immunomodulatory proteins, including those similar to transforming growth factor beta and beta-nerve growth factor.
9	14671117	CNPV genes lacking homologues in FWPV encode proteins similar to ubiquitin, interleukin-10-like proteins, tumor necrosis factor receptor, PIR1 RNA phosphatase, thioredoxin binding protein, MyD116 domain proteins, circovirus Rep proteins, and the nucleotide metabolism proteins thymidylate kinase and ribonucleotide reductase small subunit.
10	15650237	This led to the identification of three novel natural MHC class I peptide ligands: TEALPVKLI, from ribonucleotide reductase M2; NEYIMSLI, from Ser/Thr protein phosphatase 2A; and FEMVSTLI, of unknown origin.
11	21387205	Therefore, we generated KHV recombinants possessing deletions within the viral ribonucleotide reductase (RNR), thymidine kinase (TK), dUTPase, or TK and dUTPase genes, and their corresponding rescuants.
12	22443647	The monoclonal antibody to EGFR, cetuximab, improves survival in patients with metastatic NSCLC, and the inhibitor of the echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) fusion protein, crizotinib, has resulted in an unprecedented overall survival advantage in patients harboring the EML4-ALK translocation.
13	22443647	In the adjuvant setting, gefitinib has not been shown to improve patient survival outcomes; however, there are several ongoing clinical trials in the adjuvant setting evaluating the role of erlotinib, bevacizumab, and the MAGE-A3 and MUC1 vaccines.
14	22443647	Several ongoing clinical trials in both the metastatic and adjuvant settings are studying the excision repair cross-complementing group 1 (ERCC1) protein, the ribonucleotide reductase subunit 1 (RRM1) protein, thymidylate synthase, and BRCA1 as predictors of chemotherapy response.
15	23901762	PCR amplification of the RR gene in Md5deltaRR1-infected duck embryo fibroblasts (DEF) confirmed the deletion of the 2.4 kb RR1 gene with a resultant amplicon of a 640-bp fragment.
16	23907649	In the present study, we have explored the protective efficacy of antisense constructs directed against WSSV proteins, VP24, and VP28, thymidylate synthase (TS), and ribonucleotide reductase-2 (RR2) under the control of endogenous shrimp histone-3 (H3) or penaedin (Pn) promoter.
17	24675761	We identified a dominant HLA-A*0201-restricted epitope in the VZV ribonucleotide reductase subunit 2 and used a tetramer to analyze the phenotype and function of epitope-specific CD8 T cells.
18	25674983	During infection, HSV modulates cell death pathways using the large subunit (R1) of ribonucleotide reductase (RR) to suppress apoptosis by binding to and blocking caspase-8.
19	25674983	Here, we demonstrate that HSV-1 and HSV-2 R1 proteins (ICP6 and ICP10, respectively) also prevent necroptosis in human cells by inhibiting the interaction between receptor-interacting protein kinase 1 (RIP1) and RIP3, a key step in tumor necrosis factor (TNF)-induced necroptosis.
20	25674983	We show that suppression of this cell death pathway requires an N-terminal RIP homotypic interaction motif (RHIM) within R1, acting in concert with the caspase-8-binding domain, which unleashes necroptosis independent of RHIM function.
21	25828583	Receptor-interacting protein kinase (RIP)3 (also called RIPK3) mediates necrotic death by phosphorylating an executioner protein, MLKL, leading to plasma membrane leakage.
22	25828583	Recent investigations reveal a similar mechanism at play in the human alpha-herpesviruses, herpes simplex virus (HSV)1 and HSV2, where RHIM competitor function and caspase 8 suppression are carried out by the virus-encoded large subunit of ribonucleotide reductase (R1).
23	25828583	In human cells, R1 inhibition of caspase 8 prevents TNF-induced apoptosis, but sensitizes to TNF-induced necroptosis.
24	25828583	The RHIM and caspase 8 interaction domains of R1 collaborate to prevent RIP3-dependent steps and enable both herpesviruses to deflect host cell death machinery that would cut short infection.