Ignet

Gene Information

Gene symbol: SECTM1

Gene name: secreted and transmembrane 1

HGNC ID: 10707

Synonyms: K12

Related Genes

#	Gene Symbol	Number of hits
1	CD7	1 hits
2	IFNG	1 hits

Related Sentences

#	PMID	Sentence
1	15742156	Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma.
2	15742156	Recently, an epithelial cell secreted protein, K12, was identified as a CD7 ligand.
3	15742156	Although CD7 is expressed intrathymically, it is not known if K12 is produced in human thymus.
4	15742156	We found that recombinant human K12 bound strongly to soluble hCD7, with a Keq of 37.6x10(-9) M, and this interaction was inhibited by a novel antihuman K12 monoclonal antibody (K12-A1).
5	15742156	Expression of K12 in TE cells was upregulated by IFN-gamma.
6	15742156	Taken together, these data demonstrated that K12 is produced by human TE cells and thymic fibroblasts, and is regulated in thymus by IFN-gamma.
7	15742156	These data suggest a role for thymic microenvironment-produced K12 in regulation of thymocyte signaling and cytokine release, particularly in the setting of thymus pathology where IFN-gamma is upregulated such as myasthenia gravis.
8	15742156	Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma.
9	15742156	Recently, an epithelial cell secreted protein, K12, was identified as a CD7 ligand.
10	15742156	Although CD7 is expressed intrathymically, it is not known if K12 is produced in human thymus.
11	15742156	We found that recombinant human K12 bound strongly to soluble hCD7, with a Keq of 37.6x10(-9) M, and this interaction was inhibited by a novel antihuman K12 monoclonal antibody (K12-A1).
12	15742156	Expression of K12 in TE cells was upregulated by IFN-gamma.
13	15742156	Taken together, these data demonstrated that K12 is produced by human TE cells and thymic fibroblasts, and is regulated in thymus by IFN-gamma.
14	15742156	These data suggest a role for thymic microenvironment-produced K12 in regulation of thymocyte signaling and cytokine release, particularly in the setting of thymus pathology where IFN-gamma is upregulated such as myasthenia gravis.
15	15742156	Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma.
16	15742156	Recently, an epithelial cell secreted protein, K12, was identified as a CD7 ligand.
17	15742156	Although CD7 is expressed intrathymically, it is not known if K12 is produced in human thymus.
18	15742156	We found that recombinant human K12 bound strongly to soluble hCD7, with a Keq of 37.6x10(-9) M, and this interaction was inhibited by a novel antihuman K12 monoclonal antibody (K12-A1).
19	15742156	Expression of K12 in TE cells was upregulated by IFN-gamma.
20	15742156	Taken together, these data demonstrated that K12 is produced by human TE cells and thymic fibroblasts, and is regulated in thymus by IFN-gamma.
21	15742156	These data suggest a role for thymic microenvironment-produced K12 in regulation of thymocyte signaling and cytokine release, particularly in the setting of thymus pathology where IFN-gamma is upregulated such as myasthenia gravis.
22	15742156	Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma.
23	15742156	Recently, an epithelial cell secreted protein, K12, was identified as a CD7 ligand.
24	15742156	Although CD7 is expressed intrathymically, it is not known if K12 is produced in human thymus.
25	15742156	We found that recombinant human K12 bound strongly to soluble hCD7, with a Keq of 37.6x10(-9) M, and this interaction was inhibited by a novel antihuman K12 monoclonal antibody (K12-A1).
26	15742156	Expression of K12 in TE cells was upregulated by IFN-gamma.
27	15742156	Taken together, these data demonstrated that K12 is produced by human TE cells and thymic fibroblasts, and is regulated in thymus by IFN-gamma.
28	15742156	These data suggest a role for thymic microenvironment-produced K12 in regulation of thymocyte signaling and cytokine release, particularly in the setting of thymus pathology where IFN-gamma is upregulated such as myasthenia gravis.
29	15742156	Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma.
30	15742156	Recently, an epithelial cell secreted protein, K12, was identified as a CD7 ligand.
31	15742156	Although CD7 is expressed intrathymically, it is not known if K12 is produced in human thymus.
32	15742156	We found that recombinant human K12 bound strongly to soluble hCD7, with a Keq of 37.6x10(-9) M, and this interaction was inhibited by a novel antihuman K12 monoclonal antibody (K12-A1).
33	15742156	Expression of K12 in TE cells was upregulated by IFN-gamma.
34	15742156	Taken together, these data demonstrated that K12 is produced by human TE cells and thymic fibroblasts, and is regulated in thymus by IFN-gamma.
35	15742156	These data suggest a role for thymic microenvironment-produced K12 in regulation of thymocyte signaling and cytokine release, particularly in the setting of thymus pathology where IFN-gamma is upregulated such as myasthenia gravis.
36	15742156	Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma.
37	15742156	Recently, an epithelial cell secreted protein, K12, was identified as a CD7 ligand.
38	15742156	Although CD7 is expressed intrathymically, it is not known if K12 is produced in human thymus.
39	15742156	We found that recombinant human K12 bound strongly to soluble hCD7, with a Keq of 37.6x10(-9) M, and this interaction was inhibited by a novel antihuman K12 monoclonal antibody (K12-A1).
40	15742156	Expression of K12 in TE cells was upregulated by IFN-gamma.
41	15742156	Taken together, these data demonstrated that K12 is produced by human TE cells and thymic fibroblasts, and is regulated in thymus by IFN-gamma.
42	15742156	These data suggest a role for thymic microenvironment-produced K12 in regulation of thymocyte signaling and cytokine release, particularly in the setting of thymus pathology where IFN-gamma is upregulated such as myasthenia gravis.
43	15742156	Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma.
44	15742156	Recently, an epithelial cell secreted protein, K12, was identified as a CD7 ligand.
45	15742156	Although CD7 is expressed intrathymically, it is not known if K12 is produced in human thymus.
46	15742156	We found that recombinant human K12 bound strongly to soluble hCD7, with a Keq of 37.6x10(-9) M, and this interaction was inhibited by a novel antihuman K12 monoclonal antibody (K12-A1).
47	15742156	Expression of K12 in TE cells was upregulated by IFN-gamma.
48	15742156	Taken together, these data demonstrated that K12 is produced by human TE cells and thymic fibroblasts, and is regulated in thymus by IFN-gamma.
49	15742156	These data suggest a role for thymic microenvironment-produced K12 in regulation of thymocyte signaling and cytokine release, particularly in the setting of thymus pathology where IFN-gamma is upregulated such as myasthenia gravis.