Ignet

Gene Information

Gene symbol: SERPINA2

Gene name: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2

HGNC ID: 8985

Related Genes

#	Gene Symbol	Number of hits
1	ARHGEF2	1 hits
2	IFNG	1 hits
3	IL12A	1 hits
4	IL2	1 hits
5	IL6	1 hits
6	UBASH3B	1 hits

Related Sentences

#	PMID	Sentence
1	10438930	In this study four murine IL-12 naked DNA expression plasmids (pIL-12), containing both the p35 and p40 subunits, were shown to induce systemic biological effects in vivo after intradermal injection.
2	10438930	Three of the four IL-12 expression vectors augmented NK activity and induced expression of the IFN-gamma and IFN-gamma-inducible Mig genes.
3	10438930	Both IL-12 p70 heterodimer and IFN-gamma proteins were documented in the serum within 24 h after intradermal injection of the pIL-12o- plasmid, which also induced the highest level of NK activity in the spleen and liver among the IL-12 constructs.
4	10438930	Finally, injection of the pIL-12o- into BALB/c IL-12 p40-/- mice also resulted in a biphasic pattern of IL-12 p70 appearance in the serum, and induced IFN-gamma protein and activated NK lytic activity in liver and spleen.
5	15542449	Expression of an interleukin-6 - interleukin-2 fusion protein (pIL-6-IL-2) in P. pastoris.
6	15542449	Interleukin-2 and interleukin-6 can stimulate the growth and proliferation of T lymphocytes and the differentiation of activated B lymphocytes respectively, and in turn enhance cellular and humoral immune responses.
7	15542449	In this work, an expression clone using Pichia pastoris, a methylotrophic yeast strain, has been developed in order to produce large amounts of the functional recombinant fusion protein pIL-6-IL-2, which contains the mature porcine interleukin-6 peptide and the mature porcine interleukin-2 peptide.
8	15542449	This was confirmed to be pIL-6-IL-2 by means of SDS-PAGE and Western Blot analysis.
9	15542449	After treatment with PNGase F and analysis of the concentration of sugar, the fusion protein pIL-6-IL-2 was further confirmed to be mainly a glycoprotein with an approximately 2 kDa sugar decoration.
10	15542449	In addition, the IL-6 and IL-2 biological activities of the fusion protein, determined by cell proliferation assays using the IL6-dependent cell line B9 and the IL2-dependent cell line CTLL-2, reached 1 x 10(5) Umg and 8 x 10(5) Umg, respectively.
11	15542449	Expression of an interleukin-6 - interleukin-2 fusion protein (pIL-6-IL-2) in P. pastoris.
12	15542449	Interleukin-2 and interleukin-6 can stimulate the growth and proliferation of T lymphocytes and the differentiation of activated B lymphocytes respectively, and in turn enhance cellular and humoral immune responses.
13	15542449	In this work, an expression clone using Pichia pastoris, a methylotrophic yeast strain, has been developed in order to produce large amounts of the functional recombinant fusion protein pIL-6-IL-2, which contains the mature porcine interleukin-6 peptide and the mature porcine interleukin-2 peptide.
14	15542449	This was confirmed to be pIL-6-IL-2 by means of SDS-PAGE and Western Blot analysis.
15	15542449	After treatment with PNGase F and analysis of the concentration of sugar, the fusion protein pIL-6-IL-2 was further confirmed to be mainly a glycoprotein with an approximately 2 kDa sugar decoration.
16	15542449	In addition, the IL-6 and IL-2 biological activities of the fusion protein, determined by cell proliferation assays using the IL6-dependent cell line B9 and the IL2-dependent cell line CTLL-2, reached 1 x 10(5) Umg and 8 x 10(5) Umg, respectively.
17	15542449	Expression of an interleukin-6 - interleukin-2 fusion protein (pIL-6-IL-2) in P. pastoris.
18	15542449	Interleukin-2 and interleukin-6 can stimulate the growth and proliferation of T lymphocytes and the differentiation of activated B lymphocytes respectively, and in turn enhance cellular and humoral immune responses.
19	15542449	In this work, an expression clone using Pichia pastoris, a methylotrophic yeast strain, has been developed in order to produce large amounts of the functional recombinant fusion protein pIL-6-IL-2, which contains the mature porcine interleukin-6 peptide and the mature porcine interleukin-2 peptide.
20	15542449	This was confirmed to be pIL-6-IL-2 by means of SDS-PAGE and Western Blot analysis.
21	15542449	After treatment with PNGase F and analysis of the concentration of sugar, the fusion protein pIL-6-IL-2 was further confirmed to be mainly a glycoprotein with an approximately 2 kDa sugar decoration.
22	15542449	In addition, the IL-6 and IL-2 biological activities of the fusion protein, determined by cell proliferation assays using the IL6-dependent cell line B9 and the IL2-dependent cell line CTLL-2, reached 1 x 10(5) Umg and 8 x 10(5) Umg, respectively.
23	15542449	Expression of an interleukin-6 - interleukin-2 fusion protein (pIL-6-IL-2) in P. pastoris.
24	15542449	Interleukin-2 and interleukin-6 can stimulate the growth and proliferation of T lymphocytes and the differentiation of activated B lymphocytes respectively, and in turn enhance cellular and humoral immune responses.
25	15542449	In this work, an expression clone using Pichia pastoris, a methylotrophic yeast strain, has been developed in order to produce large amounts of the functional recombinant fusion protein pIL-6-IL-2, which contains the mature porcine interleukin-6 peptide and the mature porcine interleukin-2 peptide.
26	15542449	This was confirmed to be pIL-6-IL-2 by means of SDS-PAGE and Western Blot analysis.
27	15542449	After treatment with PNGase F and analysis of the concentration of sugar, the fusion protein pIL-6-IL-2 was further confirmed to be mainly a glycoprotein with an approximately 2 kDa sugar decoration.
28	15542449	In addition, the IL-6 and IL-2 biological activities of the fusion protein, determined by cell proliferation assays using the IL6-dependent cell line B9 and the IL2-dependent cell line CTLL-2, reached 1 x 10(5) Umg and 8 x 10(5) Umg, respectively.