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Gene Information

Gene symbol: SERPINB1

Gene name: serpin peptidase inhibitor, clade B (ovalbumin), member 1

HGNC ID: 3311

Synonyms: EI, PI2, anti-elastase

Related Genes

#	Gene Symbol	Number of hits
1	PEBP1	1 hits
2	SERPINA1	1 hits

Related Sentences

#	PMID	Sentence
1	18515415	Interestingly, strains belonging to CC271 (where sequence type 271 is the predicted founder of the CC) contain both PI-1 and PI-2, as revealed by genome analyses.
2	21308386	We characterized the prevalence of pilus islets 1 (PI-1) and 2 (PI-2) and the clonality of Streptococcus pneumoniae isolates taken from children with acute otitis media (AOM) to study the association between pilus existence and AOM disease potential prior to pneumococcal conjugate vaccine and increased antimicrobial resistance.
3	21308386	Isolates were studied for antimicrobial susceptibility and were serotyped, genotyped by multilocus sequence typing (MLST), and tested for the presence of pneumococcal PI-1 and PI-2 genes.
4	21308386	The importance of PI-1 in AOM infections and its association with the spread of antimicrobial resistance requires further research.
5	21308386	We characterized the prevalence of pilus islets 1 (PI-1) and 2 (PI-2) and the clonality of Streptococcus pneumoniae isolates taken from children with acute otitis media (AOM) to study the association between pilus existence and AOM disease potential prior to pneumococcal conjugate vaccine and increased antimicrobial resistance.
6	21308386	Isolates were studied for antimicrobial susceptibility and were serotyped, genotyped by multilocus sequence typing (MLST), and tested for the presence of pneumococcal PI-1 and PI-2 genes.
7	21308386	The importance of PI-1 in AOM infections and its association with the spread of antimicrobial resistance requires further research.
8	22749798	We examined the distribution of the two pilus island loci (PI-1 and PI-2) in all pediatric invasive pneumococcal disease (IPD) isolates recovered in Portugal over the ten year period 1999-2008 (n=575).
9	22749798	Only serotypes 19F and 19A contained isolates carrying simultaneously PI-1 and PI-2 and the proportion of isolates carrying both pilus islands remained stable and low.
10	22749798	We examined the distribution of the two pilus island loci (PI-1 and PI-2) in all pediatric invasive pneumococcal disease (IPD) isolates recovered in Portugal over the ten year period 1999-2008 (n=575).
11	22749798	Only serotypes 19F and 19A contained isolates carrying simultaneously PI-1 and PI-2 and the proportion of isolates carrying both pilus islands remained stable and low.
12	23722433	The presence of the pilus islets PI-1 and PI-2 was detected by PCR assays targeting a marker gene in each islet.
13	25467035	Of the 13 isolates which carried both PI-1 and PI-2, 10 were of clinical origin.
14	26363404	Because of the removal of vaccine serotype strains, positivity for one or both pilus types (PI-1 and PI-2) decreased in the post-PCV13 years 2011-2013 relative to 2008-2009 (decreases of 32-55% for PI-1, and >95% for PI-2 and combined PI-1 + PI-2). β-Lactam susceptibility phenotypes correlated consistently with transpeptidase region sequence combinations of the three major penicillin-binding proteins (PBPs) determined through WGS analysis.