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Gene Information
Gene symbol: SERPINE2
Gene name: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
HGNC ID: 8951
Synonyms: PN1, GDN, PNI, nexin
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IL10 | 1 hits |
| 2 | PLAT | 1 hits |
| 3 | SERPINE1 | 1 hits |
| 4 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11273882 | Human peritoneal mesothelial cells (HMCs) have a critical role in maintaining the intraperitoneal balance between fibrinolysis and coagulation by expressing the fibrinolytic enzyme, tissue-type plasminogen activator (tPA), as well as a specific plasminogen activator inhibitor (type 1; PAI-1). |
| 2 | 11273882 | Cultured HMCs isolated from omental biopsy specimens were used to study the effect of heat-killed strains (2 x 10(8)/mL) of Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli on the synthesis of tPA and PAI-1. |
| 3 | 11273882 | Conditioned media were obtained by incubating cells with the different bacterial strains. tPA and PAI-1 antigen concentrations were measured in the cell supernatants by enzyme-linked immunosorbent assay. |
| 4 | 11273882 | The increase in PAI-1 synthesis, not the decrease in the production of tPA, alters mesothelial fibrinolytic activity. |
| 5 | 11524916 | Recent work has emphasized the role of genetic polymorphisms in various systems to explain the most severe cases: anti-inflammatory cytokine profile IL-10/TNF-alpha, elevated levels of plasminogen activator inhibitor type-1, variants of the gene for mannose-binding lectin complement pathway. |
| 6 | 14693177 | The assay was a non-competitive sandwich enzyme-linked immunosorbent assay (ELISA) based on the production of a specific polyclonal antibody against mouse plasminogen activator inhibitor type-1 (PAI-1) used both as a trapping and detecting antibody. |
| 7 | 14693177 | The standard curve was constructed with a recombinant glutathione S-transferase (GST)-mouse PAI-1 fusion protein (GST-mPAI-1) and dose-response of the assay was linear for GST-mPAI-1 between 6.25 and 100 pM. |