Ignet

Gene Information

Gene symbol: SFTPD

Gene name: surfactant protein D

HGNC ID: 10803

Synonyms: SP-D, COLEC7

Related Genes

#	Gene Symbol	Number of hits
1	AD5	1 hits
2	ADIPOQ	1 hits
3	CD40LG	1 hits
4	CD70	1 hits
5	CD8A	1 hits
6	HOXD13	1 hits
7	IFNG	1 hits
8	LTF	1 hits
9	MBL2	1 hits
10	SFTPA1	1 hits
11	TNFSF18	1 hits

Related Sentences

#	PMID	Sentence
1	10926544	Surfactant-associated protein A (SP-A) is involved in surfactant homeostasis and host defense in the lung.
2	10926544	TNF-alpha and nitric oxide production induced by BCG were enhanced by SP-A.
3	10926544	In addition, SP-A enhanced the BCG-induced increase in the level of inducible nitric oxide synthase protein.
4	10926544	Addition of antibodies directed against SPR210, a specific macrophage SP-A receptor, inhibited the SP-A-enhanced mediator production.
5	11163458	The secreted antimicrobial molecules of the tubotympanum include lysozyme, lactoferrin, beta defensins, and the surfactant proteins A and D (SP-A, SP-D).
6	15588319	Coccidioides posadasii infection alters the expression of pulmonary surfactant proteins (SP)-A and SP-D.
7	16439533	Multimeric soluble CD40 ligand and GITR ligand as adjuvants for human immunodeficiency virus DNA vaccines.
8	16439533	CD40 ligand (CD40L), a member of the tumor necrosis factor (TNF) superfamily (TNFSF), is one candidate adjuvant, but it has been difficult to use because it is normally expressed as a trimeric membrane molecule.
9	16439533	Fusion with the body of Acrp30 was used to produce the 2-trimer form, and fusion with the body of surfactant protein D was used to produce the 4-trimer form.
10	16439533	These CD40L-augmented DNA vaccines elicited strong CD8(+) T-cell responses but did not elicit significant CD4(+) T-cell or antibody responses.
11	16439533	To test the applicability of the multimeric fusion protein approach to other TNFSFs, a 4-trimer construct for the ligand of glucocorticoid-induced TNF family-related receptor (GITR) was also prepared.
12	16439533	Multimeric soluble GITR ligand (GITRL) augmented the CD8(+) T-cell, CD4(+) T-cell, and antibody responses to DNA vaccination.
13	16439533	In summary, multimeric CD40L and GITRL are new adjuvants for DNA vaccines.
14	18288962	However, in the absence of danger, such as during the clearance of apoptotic cells, defense collagens such as C1q, MBL, ficolins, SP-A, SP-D and even adiponectin have all been shown to facilitate enhanced phagocytosis and modulate induction of cytokines towards an anti-inflammatory profile.
15	20080799	Recently, we determined that the minor pulmonary surfactant phospholipid, palmitoyl-oleoyl-phosphatidylglycerol (POPG), could markedly attenuate inflammatory responses induced by lipopolysaccharide through direct interactions with the Toll-like receptor 4 (TLR4) interacting proteins CD14 and MD-2.
16	20080799	CD14 and TLR4 have been implicated in the host response to RSV.
17	20080799	Administration of POPG to mice, concomitant with viral infection, almost completely eliminated the recovery of virus from the lungs at 3 and 5 days after infection, and abrogated IFN-gamma (IFN-gamma) production and the enhanced expression of surfactant protein D (SP-D).
18	24227853	Vaccination with a fusion protein that introduces HIV-1 gag antigen into a multitrimer CD40L construct results in enhanced CD8+ T cell responses and protection from viral challenge by vaccinia-gag.
19	24227853	CD40 ligand (CD40L, CD154) is a membrane protein that is important for the activation of dendritic cells (DCs) and DC-induced CD8(+) T cell responses.
20	24227853	To be active, CD40L must cluster CD40 receptors on responding cells.
21	24227853	To produce a soluble form of CD40L that clusters CD40 receptors necessitates the use of a multitrimer construct.
22	24227853	With this in mind, a tripartite fusion protein was made from surfactant protein D (SPD), HIV-1 Gag as a test antigen, and CD40L, where SPD serves as a scaffold for the multitrimer protein complex.
23	24227853	This SPD-Gag-CD40L protein activated CD40-bearing cells and bone marrow-derived DCs in vitro.
24	24227853	Compared to a plasmid for Gag antigen alone (pGag), DNA vaccination of mice with pSPD-Gag-CD40L induced an increased number of Gag-specific CD8(+) T cells with increased avidity for major histocompatibility complex class I-restricted Gag peptide and improved vaccine-induced protection from challenge by vaccinia-Gag virus.
25	24227853	This plasmid, pTrimer-Gag-CD40L, was only weakly active on CD40-bearing cells and did not elicit strong CD8(+) T cell responses or improve protection from vaccinia-Gag challenge.
26	24227853	Overall, these results show the potential of a new vaccine design in which antigen is introduced into a construct that expresses a multitrimer soluble form of CD40L, leading to strongly protective CD8(+) T cell responses.
27	24227853	Vaccination with a fusion protein that introduces HIV-1 gag antigen into a multitrimer CD40L construct results in enhanced CD8+ T cell responses and protection from viral challenge by vaccinia-gag.
28	24227853	CD40 ligand (CD40L, CD154) is a membrane protein that is important for the activation of dendritic cells (DCs) and DC-induced CD8(+) T cell responses.
29	24227853	To be active, CD40L must cluster CD40 receptors on responding cells.
30	24227853	To produce a soluble form of CD40L that clusters CD40 receptors necessitates the use of a multitrimer construct.
31	24227853	With this in mind, a tripartite fusion protein was made from surfactant protein D (SPD), HIV-1 Gag as a test antigen, and CD40L, where SPD serves as a scaffold for the multitrimer protein complex.
32	24227853	This SPD-Gag-CD40L protein activated CD40-bearing cells and bone marrow-derived DCs in vitro.
33	24227853	Compared to a plasmid for Gag antigen alone (pGag), DNA vaccination of mice with pSPD-Gag-CD40L induced an increased number of Gag-specific CD8(+) T cells with increased avidity for major histocompatibility complex class I-restricted Gag peptide and improved vaccine-induced protection from challenge by vaccinia-Gag virus.
34	24227853	This plasmid, pTrimer-Gag-CD40L, was only weakly active on CD40-bearing cells and did not elicit strong CD8(+) T cell responses or improve protection from vaccinia-Gag challenge.
35	24227853	Overall, these results show the potential of a new vaccine design in which antigen is introduced into a construct that expresses a multitrimer soluble form of CD40L, leading to strongly protective CD8(+) T cell responses.
36	24587225	Here we describe Ad5 vaccines for HIV-1 Gag antigen (Ad5-Gag) adjuvanted with the TNFSF ligands 4-1BBL, BAFF, GITRL and CD27L constructed as soluble multi-trimeric proteins via fusion to Surfactant Protein D (SP-D) as a multimerization scaffold.
37	26241951	A multi-trimeric fusion of CD40L and gp100 tumor antigen activates dendritic cells and enhances survival in a B16-F10 melanoma DNA vaccine model.
38	26241951	The spontaneously-multimerizing gene Surfactant Protein D (SPD) was used to fuse gp100 tumor antigen and CD40L, creating the recombinant protein SPD-gp100-CD40L.
39	26241951	DNA vaccination with SPD-gp100-CD40L plasmid, together with plasmids encoding IL-12p70 and GM-CSF, significantly enhanced survival and inhibited tumor growth in a B16-F10 melanoma model.
40	26241951	These data support a model where DNA vaccination with SPD-gp100-CD40L targets gp100 to DC in situ, induces activation of these DC, and generates a protective anti-tumor response when given in combination with IL-12p70 and GM-CSF plasmids.