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Gene Information
Gene symbol: SIGLEC12
Gene name: sialic acid binding Ig-like lectin 12 (gene/pseudogene)
HGNC ID: 15482
Synonyms: SLG, S2V, Siglec-XII, Siglec-12, Siglec-L1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | SIGLEC7 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 25000981 | Lipids from mycobacteria can be presented to human T cells by group 1 CD1 Ag-presenting molecules (CD1a, CD1b, and CD1c). |
| 2 | 25000981 | In this study we show that the mycobacterial lipid Ag C80 glucose-6-monomycolate can be delivered to human CD1b(+) DCs via targeted liposomal nanoparticles, leading to robust group 1 CD1-restricted activation of T cells. |
| 3 | 25000981 | Targeting was achieved by decorating the liposomes with a high-affinity glycan ligand of sialic acid-binding Ig-like lectin (Siglec)-7, a siglec receptor expressed on DCs that mediates rapid endocytosis and transport of its cargo to lysosomes. |
| 4 | 25000981 | Mo-DCs pulsed with targeted liposomes containing C80 glucose-6-monomycolate more potently activated a CD1b-restricted T cell line relative to Mo-DCs pulsed with free lipid Ag or antigenic liposomes without Siglec-7 ligand. |