Ignet

Gene Information

Gene symbol: SLMAP

Gene name: sarcolemma associated protein

HGNC ID: 16643

Synonyms: SLAP, KIAA1601

Related Genes

#	Gene Symbol	Number of hits
1	CD4	1 hits
2	IFNG	1 hits
3	IL10	1 hits
4	IL12A	1 hits
5	IL4	1 hits
6	TH1L	1 hits

Related Sentences

#	PMID	Sentence
1	8648120	Immunization of mice with one or two doses of SLAP + IL-12 elicited a dominant population of Ag-specific Th1 lymphocytes in the draining lymph nodes, as judged by the secretion of abundant IFN-gamma but undetectable levels of IL-4, upon antigenic restimulation in vitro.
2	8648120	In contrast, SLAP alone induced a mixed population of Th1 and Th2 cells with secretion of IFN-gamma, IL-4, and IL-10.
3	8648120	The development of a biased Th1 cell population in mice immunized with SLAP + IL-12 was reflected in enhanced levels of Ag-specific IgG2a but decreased levels of IgG1 and total IgE serum Abs.
4	8648120	Ablation of NK1.1+ cells before the administration of a single dose of SLAP + IL-12 reduced Th cell proliferation and almost completely inhibited secretion of IFN-gamma by in vitro-cultured lymph node cells.
5	8648120	Finally, it is demonstrated that the delivery of two doses of SLAP + IL-12 to mice is sufficient to elicit moderate but highly significant levels of protective immunity against challenge infection.
6	8648120	Immunization of mice with one or two doses of SLAP + IL-12 elicited a dominant population of Ag-specific Th1 lymphocytes in the draining lymph nodes, as judged by the secretion of abundant IFN-gamma but undetectable levels of IL-4, upon antigenic restimulation in vitro.
7	8648120	In contrast, SLAP alone induced a mixed population of Th1 and Th2 cells with secretion of IFN-gamma, IL-4, and IL-10.
8	8648120	The development of a biased Th1 cell population in mice immunized with SLAP + IL-12 was reflected in enhanced levels of Ag-specific IgG2a but decreased levels of IgG1 and total IgE serum Abs.
9	8648120	Ablation of NK1.1+ cells before the administration of a single dose of SLAP + IL-12 reduced Th cell proliferation and almost completely inhibited secretion of IFN-gamma by in vitro-cultured lymph node cells.
10	8648120	Finally, it is demonstrated that the delivery of two doses of SLAP + IL-12 to mice is sufficient to elicit moderate but highly significant levels of protective immunity against challenge infection.
11	8648120	Immunization of mice with one or two doses of SLAP + IL-12 elicited a dominant population of Ag-specific Th1 lymphocytes in the draining lymph nodes, as judged by the secretion of abundant IFN-gamma but undetectable levels of IL-4, upon antigenic restimulation in vitro.
12	8648120	In contrast, SLAP alone induced a mixed population of Th1 and Th2 cells with secretion of IFN-gamma, IL-4, and IL-10.
13	8648120	The development of a biased Th1 cell population in mice immunized with SLAP + IL-12 was reflected in enhanced levels of Ag-specific IgG2a but decreased levels of IgG1 and total IgE serum Abs.
14	8648120	Ablation of NK1.1+ cells before the administration of a single dose of SLAP + IL-12 reduced Th cell proliferation and almost completely inhibited secretion of IFN-gamma by in vitro-cultured lymph node cells.
15	8648120	Finally, it is demonstrated that the delivery of two doses of SLAP + IL-12 to mice is sufficient to elicit moderate but highly significant levels of protective immunity against challenge infection.
16	8648120	Immunization of mice with one or two doses of SLAP + IL-12 elicited a dominant population of Ag-specific Th1 lymphocytes in the draining lymph nodes, as judged by the secretion of abundant IFN-gamma but undetectable levels of IL-4, upon antigenic restimulation in vitro.
17	8648120	In contrast, SLAP alone induced a mixed population of Th1 and Th2 cells with secretion of IFN-gamma, IL-4, and IL-10.
18	8648120	The development of a biased Th1 cell population in mice immunized with SLAP + IL-12 was reflected in enhanced levels of Ag-specific IgG2a but decreased levels of IgG1 and total IgE serum Abs.
19	8648120	Ablation of NK1.1+ cells before the administration of a single dose of SLAP + IL-12 reduced Th cell proliferation and almost completely inhibited secretion of IFN-gamma by in vitro-cultured lymph node cells.
20	8648120	Finally, it is demonstrated that the delivery of two doses of SLAP + IL-12 to mice is sufficient to elicit moderate but highly significant levels of protective immunity against challenge infection.
21	8648120	Immunization of mice with one or two doses of SLAP + IL-12 elicited a dominant population of Ag-specific Th1 lymphocytes in the draining lymph nodes, as judged by the secretion of abundant IFN-gamma but undetectable levels of IL-4, upon antigenic restimulation in vitro.
22	8648120	In contrast, SLAP alone induced a mixed population of Th1 and Th2 cells with secretion of IFN-gamma, IL-4, and IL-10.
23	8648120	The development of a biased Th1 cell population in mice immunized with SLAP + IL-12 was reflected in enhanced levels of Ag-specific IgG2a but decreased levels of IgG1 and total IgE serum Abs.
24	8648120	Ablation of NK1.1+ cells before the administration of a single dose of SLAP + IL-12 reduced Th cell proliferation and almost completely inhibited secretion of IFN-gamma by in vitro-cultured lymph node cells.
25	8648120	Finally, it is demonstrated that the delivery of two doses of SLAP + IL-12 to mice is sufficient to elicit moderate but highly significant levels of protective immunity against challenge infection.
26	9686195	Elevated levels of IL-12 (p40 mRNA) were detected in the lymph nodes (LN) and the lungs of vaccinated mice, whilst treatment of vaccinated mice with anti-IL-12 antibodies decreased the ratio of IFN gamma:IL-4 secreted by in vitro-cultured LN cells.
27	9686195	Soluble antigens from the lung-stage of the parasite (SLAP) appeared to be efficient stimulators of IFN gamma and IL-12 secretion.
28	9686195	These antigens when used to immunise mice in conjunction with IL-12 as an adjuvant, elicited a polarised Th1 response with abundant IFN gamma secretion but no IL-4.
29	9686195	The induction of a dominant Th1 response using SLAP + IL-12 probably operates via IFN gamma production by natural killer (NK) cells stimulated by IL-12, since in vivo ablation of NK cells using anti-NK1.1 antibody reduced CD4(+)-dependent IFN gamma production from cultured LN cells by over 97%.
30	9686195	Nevertheless, in mice with a genetic disruption of the IFN gamma receptor, administration of SLAP + IL-12 induced levels of IFN gamma equal to those in wild-type mice, thus showing that in this model IL-12 can directly prime T cells independent of IFN gamma.
31	9686195	Elevated levels of IL-12 (p40 mRNA) were detected in the lymph nodes (LN) and the lungs of vaccinated mice, whilst treatment of vaccinated mice with anti-IL-12 antibodies decreased the ratio of IFN gamma:IL-4 secreted by in vitro-cultured LN cells.
32	9686195	Soluble antigens from the lung-stage of the parasite (SLAP) appeared to be efficient stimulators of IFN gamma and IL-12 secretion.
33	9686195	These antigens when used to immunise mice in conjunction with IL-12 as an adjuvant, elicited a polarised Th1 response with abundant IFN gamma secretion but no IL-4.
34	9686195	The induction of a dominant Th1 response using SLAP + IL-12 probably operates via IFN gamma production by natural killer (NK) cells stimulated by IL-12, since in vivo ablation of NK cells using anti-NK1.1 antibody reduced CD4(+)-dependent IFN gamma production from cultured LN cells by over 97%.
35	9686195	Nevertheless, in mice with a genetic disruption of the IFN gamma receptor, administration of SLAP + IL-12 induced levels of IFN gamma equal to those in wild-type mice, thus showing that in this model IL-12 can directly prime T cells independent of IFN gamma.
36	16605124	Different Schistosoma mansoni antigens; adult worm antigen (SWAP) and lung-stage antigen (SLAP) together with different cytokine adjuvants (Interferon-gamma and Interleukin-4) were used to immunize mice against.
37	16605124	SLAP plus IFN-gamma as an adjuvant was the best immunization regimen with almost 50% protection and a remarkable resolving of parasite pathology.