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Gene Information
Gene symbol: STK11
Gene name: serine/threonine kinase 11
HGNC ID: 11389
Synonyms: PJS, LKB1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD274 | 1 hits |
| 2 | KRT5 | 1 hits |
| 3 | PRKAA2 | 1 hits |
| 4 | PTEN | 1 hits |
| 5 | SOX2 | 1 hits |
| 6 | TP63 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 22532801 | We show restriction of RVFV both by AMPK and its upstream activator LKB1, indicating an antiviral role for this signaling pathway. |
| 2 | 22532801 | Lastly, we found that this pathway plays a broad role in antiviral defense since additional viruses from disparate families were also restricted by AMPK and LKB1. |
| 3 | 22532801 | We show restriction of RVFV both by AMPK and its upstream activator LKB1, indicating an antiviral role for this signaling pathway. |
| 4 | 22532801 | Lastly, we found that this pathway plays a broad role in antiviral defense since additional viruses from disparate families were also restricted by AMPK and LKB1. |
| 5 | 24794706 | Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression. |
| 6 | 24794706 | We demonstrate that biallelic inactivation of Lkb1 and Pten in the mouse lung leads to SCC that recapitulates the histology, gene expression, and microenvironment found in human disease. |
| 7 | 24794706 | Lkb1;Pten null (LP) tumors expressed the squamous markers KRT5, p63 and SOX2, and transcriptionally resembled the basal subtype of human SCC. |
| 8 | 24794706 | SCA1(+)NGFR(+) fractions were enriched for tumor-propagating cells (TPCs) that could serially transplant the disease in orthotopic assays. |
| 9 | 24794706 | Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression. |
| 10 | 24794706 | We demonstrate that biallelic inactivation of Lkb1 and Pten in the mouse lung leads to SCC that recapitulates the histology, gene expression, and microenvironment found in human disease. |
| 11 | 24794706 | Lkb1;Pten null (LP) tumors expressed the squamous markers KRT5, p63 and SOX2, and transcriptionally resembled the basal subtype of human SCC. |
| 12 | 24794706 | SCA1(+)NGFR(+) fractions were enriched for tumor-propagating cells (TPCs) that could serially transplant the disease in orthotopic assays. |
| 13 | 24794706 | Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression. |
| 14 | 24794706 | We demonstrate that biallelic inactivation of Lkb1 and Pten in the mouse lung leads to SCC that recapitulates the histology, gene expression, and microenvironment found in human disease. |
| 15 | 24794706 | Lkb1;Pten null (LP) tumors expressed the squamous markers KRT5, p63 and SOX2, and transcriptionally resembled the basal subtype of human SCC. |
| 16 | 24794706 | SCA1(+)NGFR(+) fractions were enriched for tumor-propagating cells (TPCs) that could serially transplant the disease in orthotopic assays. |