Ignet

Gene Information

Gene symbol: STX2

Gene name: syntaxin 2

HGNC ID: 3403

Synonyms: EPM

Related Genes

#	Gene Symbol	Number of hits
1	CD79A	1 hits
2	H19	1 hits
3	HRB	1 hits
4	KRT12	1 hits
5	STX1A	1 hits
6	STX1B	1 hits

Related Sentences

#	PMID	Sentence
1	10531288	Strains causing HUS contain either Shiga toxin 1 (Stx1) or Stx2, or both.
2	11133375	The Shiga toxins Stx1 and Stx2 contribute to the development of enterohemorrhagic O157:H7 Escherichia coli-mediated colitis and hemolytic-uremic syndrome in humans.
3	15557626	Phage 2851 showed lysis of E. coli K-12 strains lysogenic for Stx phages encoding Stx1 (H19), Stx2 (933W), Stx (7888), and Stx1c (6220) but showed superinfection immunity with phage lambda, presumably originating from the similarity of the cI repressor proteins of both phages.
4	15557626	Apparently, phage 2851 integrates at a different chromosomal locus than Stx2 phage 933W and Stx1 phage H19 in E. coli, explaining why Stx2c is often found in combination with Stx1 or Stx2 in E. coli O157 strains.
5	15557626	Phage 2851 showed lysis of E. coli K-12 strains lysogenic for Stx phages encoding Stx1 (H19), Stx2 (933W), Stx (7888), and Stx1c (6220) but showed superinfection immunity with phage lambda, presumably originating from the similarity of the cI repressor proteins of both phages.
6	15557626	Apparently, phage 2851 integrates at a different chromosomal locus than Stx2 phage 933W and Stx1 phage H19 in E. coli, explaining why Stx2c is often found in combination with Stx1 or Stx2 in E. coli O157 strains.
7	16177326	These conditions arise because EHEC produces two antigenically distinct forms of Shiga toxin (Stx), called Stx1 and Stx2.
8	16198455	Whether antisera to Stx1 or Stx2 are cross-neutralizing remains controversial, so we constructed genetic toxoids of Stx1 and Stx2 and evaluated them as vaccines.
9	16198455	Furthermore, only mice immunized with Stx1 and Stx2 toxoids were protected against a lethal challenge of both toxins.
10	16198455	We conclude that Stx1 and Stx2 are distinct antigens for mice.
11	16198455	Whether antisera to Stx1 or Stx2 are cross-neutralizing remains controversial, so we constructed genetic toxoids of Stx1 and Stx2 and evaluated them as vaccines.
12	16198455	Furthermore, only mice immunized with Stx1 and Stx2 toxoids were protected against a lethal challenge of both toxins.
13	16198455	We conclude that Stx1 and Stx2 are distinct antigens for mice.
14	16198455	Whether antisera to Stx1 or Stx2 are cross-neutralizing remains controversial, so we constructed genetic toxoids of Stx1 and Stx2 and evaluated them as vaccines.
15	16198455	Furthermore, only mice immunized with Stx1 and Stx2 toxoids were protected against a lethal challenge of both toxins.
16	16198455	We conclude that Stx1 and Stx2 are distinct antigens for mice.
17	16551486	An STEC isolate can express Stx1, Stx2, or both, but antisera to Stx1 and Stx2 are not cross-neutralizing.
18	16641102	The immunized mice produced Stx2-specific mucosal IgA and Stx2-neutralizing serum IgG.
19	18387720	Enterohemorrhagic Escherichia coli (EHEC) produces Stx1 and Stx2 causing severe diseases.
20	18387720	Mice vaccinated with Stx2B-His plus mLT had antibodies reacting Stx1B and showed the resistance to toxemia of Stx1 and Stx2.
21	18387720	Enterohemorrhagic Escherichia coli (EHEC) produces Stx1 and Stx2 causing severe diseases.
22	18387720	Mice vaccinated with Stx2B-His plus mLT had antibodies reacting Stx1B and showed the resistance to toxemia of Stx1 and Stx2.
23	20199568	In an attempt to produce STxA-deficient OMVs from E. coli O157:H7, site-specific deletions of the stx1A and stx2A subunit genes were carried out.
24	20199568	The STxA-deficient phenotype of the stx1A/stx2A mutant was confirmed by Vero cell cytotoxicity and VTEC-RPLA assay.
25	20199568	In an attempt to produce STxA-deficient OMVs from E. coli O157:H7, site-specific deletions of the stx1A and stx2A subunit genes were carried out.
26	20199568	The STxA-deficient phenotype of the stx1A/stx2A mutant was confirmed by Vero cell cytotoxicity and VTEC-RPLA assay.
27	21455295	Shiga-like toxins (Stx1 and Stx2), produced by Escherichia coli, are RIPs that cause outbreaks of foodborne diseases with significant morbidity and mortality.
28	21664401	An antibody among the selected clones designated B22 bound to the binding subunits of both Stx-1 and Stx-2, and strongly neutralized the cytotoxicity of Stx-1.
29	21742003	In this study, a novel SSI fusion protein that contains the critical toxin-antigens Stx2B and Stx1B, and the critical adhesion-antigen fragment Int281 was constructed.
30	21742003	The dominant increase in IgG1 and the high level of Th2-typical cytokine (IL-4 and IL-10) expression showed that SSI significantly induced Th2-mediated humoral immune response.
31	21742003	In the mouse model, the SSI fusion protein not only elicited neutralizing antibodies against both Stx1 and Stx2 toxins, but also induced a high level of anti-adhesion antibodies.
32	21742003	In this study, a novel SSI fusion protein that contains the critical toxin-antigens Stx2B and Stx1B, and the critical adhesion-antigen fragment Int281 was constructed.
33	21742003	The dominant increase in IgG1 and the high level of Th2-typical cytokine (IL-4 and IL-10) expression showed that SSI significantly induced Th2-mediated humoral immune response.
34	21742003	In the mouse model, the SSI fusion protein not only elicited neutralizing antibodies against both Stx1 and Stx2 toxins, but also induced a high level of anti-adhesion antibodies.
35	23105978	Thus, the aim of this work was the characterization of the interaction between MAbs against Stx1 and Stx2 toxins and their neutralizing abilities to enable their use as tools for diagnosis and therapy.
36	23157558	Serotypes of Stx produced by EHEC include Stx1 and Stx2.
37	25716230	STEC can produce one or more types of Stx, Stx1 and/or Stx2, and Stx1 and Stx2 are responsible for HUS-mediated kidney damage.
38	25716230	We previously generated two monoclonal antibodies (MAbs) that neutralize the toxicity of Stx1 or Stx2.
39	25716230	Since many STEC strains produce both Stx1 and Stx2 and since either toxin may lead to the HUS, we also assessed the protective efficacy of the combined MAbs.
40	25716230	We found that both antibodies were required to protect mice from the presence of both Stx1 and Stx2.
41	25716230	STEC can produce one or more types of Stx, Stx1 and/or Stx2, and Stx1 and Stx2 are responsible for HUS-mediated kidney damage.
42	25716230	We previously generated two monoclonal antibodies (MAbs) that neutralize the toxicity of Stx1 or Stx2.
43	25716230	Since many STEC strains produce both Stx1 and Stx2 and since either toxin may lead to the HUS, we also assessed the protective efficacy of the combined MAbs.
44	25716230	We found that both antibodies were required to protect mice from the presence of both Stx1 and Stx2.
45	25716230	STEC can produce one or more types of Stx, Stx1 and/or Stx2, and Stx1 and Stx2 are responsible for HUS-mediated kidney damage.
46	25716230	We previously generated two monoclonal antibodies (MAbs) that neutralize the toxicity of Stx1 or Stx2.
47	25716230	Since many STEC strains produce both Stx1 and Stx2 and since either toxin may lead to the HUS, we also assessed the protective efficacy of the combined MAbs.
48	25716230	We found that both antibodies were required to protect mice from the presence of both Stx1 and Stx2.
49	25716230	STEC can produce one or more types of Stx, Stx1 and/or Stx2, and Stx1 and Stx2 are responsible for HUS-mediated kidney damage.
50	25716230	We previously generated two monoclonal antibodies (MAbs) that neutralize the toxicity of Stx1 or Stx2.
51	25716230	Since many STEC strains produce both Stx1 and Stx2 and since either toxin may lead to the HUS, we also assessed the protective efficacy of the combined MAbs.
52	25716230	We found that both antibodies were required to protect mice from the presence of both Stx1 and Stx2.
53	25889651	Immunization of calves with rStx1mut plus rStx2mut led to induction of antibodies neutralizing Stx1 and Stx2.