Ignet

Gene Information

Gene symbol: TAOK2

Gene name: TAO kinase 2

HGNC ID: 16835

Synonyms: TAO1, KIAA0881, PSK, PSK1, TAO2, MAP3K17

Related Genes

#	Gene Symbol	Number of hits
1	CD40	1 hits
2	CD80	1 hits
3	CD86	1 hits
4	CLEC7A	1 hits
5	IL1B	1 hits
6	IL6	1 hits
7	TLR2	1 hits
8	TNF	1 hits

Related Sentences

#	PMID	Sentence
1	15254744	OK432 and PSK were examined in vitro, and compared with lipopolysaccharide (LPS) and a cytokine cocktail (IL-1beta, TNF-alpha, IL-6 and PGE2).
2	15254744	In the immunophenotypical analysis, the expression of CD80 and CD83 of DCs stimulated with OK-432 increased significantly compared with PSK and medium, and this up-regulation was the same as levels of DCs stimulated with cytokine cocktail.
3	15254744	DCs stimulated with OK-432 showed significantly higher production of IL-12 and Th1-type cytokines (IL-2 and IFN-gamma) compared with DCs stimulated with LPS or cytokine cocktail.
4	23735481	In vitro experiments using mouse bone marrow-derived DC (BMDC) demonstrated that PSK induces DC maturation as shown by dose-dependent increase in the expression of CD80, CD86, MHCII, and CD40.
5	25510899	The ability of PSK to activate dendritic cells and T cells is dependent on its ability to stimulate Toll-like receptor 2 (TLR2), yet it remains unknown which structural component within PSK activates TLR2.
6	25510899	The purpose of this study was to identify the TLR2 agonist within PSK and understand its role in the overall mechanism of PSK's immunogenic activity.
7	25510899	TLR2 activity was eliminated by treatment with lipoprotein lipase but not by trypsin or lyticase.
8	25510899	Rapid centrifugation of PSK can separate the fraction with TLR2 agonist activity from the soluble β-glucan fraction.
9	25510899	Altogether, these results present evidence that PSK has two active components-the well-characterized protein-bound β-glucan and a previously unreported lipid-which work synergistically via the Dectin-1 and TLR2 receptors.
10	25510899	The ability of PSK to activate dendritic cells and T cells is dependent on its ability to stimulate Toll-like receptor 2 (TLR2), yet it remains unknown which structural component within PSK activates TLR2.
11	25510899	The purpose of this study was to identify the TLR2 agonist within PSK and understand its role in the overall mechanism of PSK's immunogenic activity.
12	25510899	TLR2 activity was eliminated by treatment with lipoprotein lipase but not by trypsin or lyticase.
13	25510899	Rapid centrifugation of PSK can separate the fraction with TLR2 agonist activity from the soluble β-glucan fraction.
14	25510899	Altogether, these results present evidence that PSK has two active components-the well-characterized protein-bound β-glucan and a previously unreported lipid-which work synergistically via the Dectin-1 and TLR2 receptors.
15	25510899	The ability of PSK to activate dendritic cells and T cells is dependent on its ability to stimulate Toll-like receptor 2 (TLR2), yet it remains unknown which structural component within PSK activates TLR2.
16	25510899	The purpose of this study was to identify the TLR2 agonist within PSK and understand its role in the overall mechanism of PSK's immunogenic activity.
17	25510899	TLR2 activity was eliminated by treatment with lipoprotein lipase but not by trypsin or lyticase.
18	25510899	Rapid centrifugation of PSK can separate the fraction with TLR2 agonist activity from the soluble β-glucan fraction.
19	25510899	Altogether, these results present evidence that PSK has two active components-the well-characterized protein-bound β-glucan and a previously unreported lipid-which work synergistically via the Dectin-1 and TLR2 receptors.
20	25510899	The ability of PSK to activate dendritic cells and T cells is dependent on its ability to stimulate Toll-like receptor 2 (TLR2), yet it remains unknown which structural component within PSK activates TLR2.
21	25510899	The purpose of this study was to identify the TLR2 agonist within PSK and understand its role in the overall mechanism of PSK's immunogenic activity.
22	25510899	TLR2 activity was eliminated by treatment with lipoprotein lipase but not by trypsin or lyticase.
23	25510899	Rapid centrifugation of PSK can separate the fraction with TLR2 agonist activity from the soluble β-glucan fraction.
24	25510899	Altogether, these results present evidence that PSK has two active components-the well-characterized protein-bound β-glucan and a previously unreported lipid-which work synergistically via the Dectin-1 and TLR2 receptors.