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Gene Information
Gene symbol: TCEB1
Gene name: transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
HGNC ID: 11617
Synonyms: SIII
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CUL2 | 1 hits |
| 2 | PTPN11 | 1 hits |
| 3 | RN7SK | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17251292 | Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase. |
| 2 | 17251292 | Degradation of STAT2 requires proteasomal activity and is dependent on the expression of RSV NS1 and NS2 (NS1/2). |
| 3 | 17251292 | Here we investigate whether RSV NS proteins can assemble ubiquitin ligase (E3) enzymes to target STAT2 to the proteasome. |
| 4 | 17251292 | We demonstrate that NS1 contains elongin C and cullin 2 binding consensus sequences and can interact with elongin C and cullin 2 in vitro; therefore, NS1 has the potential to act as an E3 ligase. |
| 5 | 17251292 | By knocking down expression of specific endogenous E3 ligase components using small interfering RNA, NS1/2, or RSV-induced STAT2, degradation is prevented. |
| 6 | 23392246 | The Tat-TAR interaction thereby recruits active positive transcription elongation factor b (P-TEFb) from its inactive, 7SK/HEXIM1-bound form, leading to efficient viral transcription. |