About

Home

Introduction

Statistics

Programs

Dignet

Gene

GenePair

BioSummarAI

Help & Docs

Documents

Help

FAQs

Links

Acknowledge

Disclaimer

Contact Us

Gene Information

Gene symbol: TCF3

Gene name: transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)

HGNC ID: 11633

Synonyms: E2A, ITF1, MGC129647, MGC129648, bHLHb21, VDIR, E47

Related Genes

#	Gene Symbol	Number of hits
1	AICDA	1 hits
2	BCKDHB	1 hits
3	DBT	1 hits
4	ERBB2	1 hits

Related Sentences

#	PMID	Sentence
1	8438562	The mutants were assessed for their ability to bind E2a, E2b, and E2c MAbs in an enzyme-linked immunosorbent assay, to induce fatal disease in neonatal mice following subcutaneous or intracranial inoculation and to compete with wild-type virus for binding to unfractionated neonatal mouse brain cells.
2	8438562	None of the substitutions affected binding of E2a or E2b MAbs, and decreased binding to E2c MAbs was correlated with decreased virulence in neonatal mice.
3	8438562	The mutants were assessed for their ability to bind E2a, E2b, and E2c MAbs in an enzyme-linked immunosorbent assay, to induce fatal disease in neonatal mice following subcutaneous or intracranial inoculation and to compete with wild-type virus for binding to unfractionated neonatal mouse brain cells.
4	8438562	None of the substitutions affected binding of E2a or E2b MAbs, and decreased binding to E2c MAbs was correlated with decreased virulence in neonatal mice.
5	11544306	A panel of E2 DNA vaccines were constructed, and their vaccination efficacy was ranked as E2 > tyrosine kinase-deficient ErbB-2 (E2A) > full-length ErbB-2 targeted to the cytoplasm (cytE2) > tyrosine kinase-deficient cytE2 (cytE2A).
6	11544306	Covaccination with cytE2A and GM-CSF or IL-2 DNA resulted in equivalent anti-tumor activity as E2.
7	11544306	ErbB-2-specific CTL were detected in mice immunized with cytE2A and GM-CSF and have rejected tumor challenge.
8	11544306	Depletion of CD8, but not CD4 T cells reduced anti-tumor immunity, indicating CTL as the effector cells.
9	15826912	However, mutant PAdV-3s containing deletion including authentic E1A promoter region, displayed both reduced steady-state levels of early gene mRNAs (E1A, E1B, E2A, E3, and E4) and decreased rate of viral replication in ST cells.
10	15996480	Our preliminary results in humans indicate similar reductions: we show herein that the expression of E2A and AID progressively decline with age.
11	18390709	Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells.
12	18390709	Our results obtained with activated CD19(+) B cells show that the expression of E47, AID, and Iggamma1 circle transcripts progressively decrease with age.
13	18390709	We also show an age-related decline in the percentage of switch memory B cells (IgG(+)/IgA(+)), an increase in that of naive B cells (IgG(-)/IgA(-)/CD27(-)) for most individuals, and no decrease in that of IgM memory cells in peripheral blood, consistent with our data on the decrease seen in class switch recombination in vitro.