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PMID |
Sentence |
1 |
24474761
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Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells.
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24474761
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We show that Tet1 and Tet2 have distinct roles in regulating 5hmC in mouse embryonic stem cells (mESC).
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24474761
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Tet1 depletion diminishes 5hmC levels at transcription start sites (TSS), whereas Tet2 depletion is predominantly associated with decreased 5hmC in gene bodies.
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24474761
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In contrast, at promoter/TSS regions, Tet2 depletion results in increased 5hmC, potentially because of the redundant activity of Tet1.
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5 |
24474761
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Together, the data point to a complex interplay between Tet1 and Tet2 in mESC, and to distinct roles for these two proteins in regulating promoter, exon, and polyadenylation site usage in cells.
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6 |
24474761
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Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells.
|
7 |
24474761
|
We show that Tet1 and Tet2 have distinct roles in regulating 5hmC in mouse embryonic stem cells (mESC).
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8 |
24474761
|
Tet1 depletion diminishes 5hmC levels at transcription start sites (TSS), whereas Tet2 depletion is predominantly associated with decreased 5hmC in gene bodies.
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9 |
24474761
|
In contrast, at promoter/TSS regions, Tet2 depletion results in increased 5hmC, potentially because of the redundant activity of Tet1.
|
10 |
24474761
|
Together, the data point to a complex interplay between Tet1 and Tet2 in mESC, and to distinct roles for these two proteins in regulating promoter, exon, and polyadenylation site usage in cells.
|
11 |
24474761
|
Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells.
|
12 |
24474761
|
We show that Tet1 and Tet2 have distinct roles in regulating 5hmC in mouse embryonic stem cells (mESC).
|
13 |
24474761
|
Tet1 depletion diminishes 5hmC levels at transcription start sites (TSS), whereas Tet2 depletion is predominantly associated with decreased 5hmC in gene bodies.
|
14 |
24474761
|
In contrast, at promoter/TSS regions, Tet2 depletion results in increased 5hmC, potentially because of the redundant activity of Tet1.
|
15 |
24474761
|
Together, the data point to a complex interplay between Tet1 and Tet2 in mESC, and to distinct roles for these two proteins in regulating promoter, exon, and polyadenylation site usage in cells.
|
16 |
24474761
|
Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells.
|
17 |
24474761
|
We show that Tet1 and Tet2 have distinct roles in regulating 5hmC in mouse embryonic stem cells (mESC).
|
18 |
24474761
|
Tet1 depletion diminishes 5hmC levels at transcription start sites (TSS), whereas Tet2 depletion is predominantly associated with decreased 5hmC in gene bodies.
|
19 |
24474761
|
In contrast, at promoter/TSS regions, Tet2 depletion results in increased 5hmC, potentially because of the redundant activity of Tet1.
|
20 |
24474761
|
Together, the data point to a complex interplay between Tet1 and Tet2 in mESC, and to distinct roles for these two proteins in regulating promoter, exon, and polyadenylation site usage in cells.
|
21 |
24474761
|
Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells.
|
22 |
24474761
|
We show that Tet1 and Tet2 have distinct roles in regulating 5hmC in mouse embryonic stem cells (mESC).
|
23 |
24474761
|
Tet1 depletion diminishes 5hmC levels at transcription start sites (TSS), whereas Tet2 depletion is predominantly associated with decreased 5hmC in gene bodies.
|
24 |
24474761
|
In contrast, at promoter/TSS regions, Tet2 depletion results in increased 5hmC, potentially because of the redundant activity of Tet1.
|
25 |
24474761
|
Together, the data point to a complex interplay between Tet1 and Tet2 in mESC, and to distinct roles for these two proteins in regulating promoter, exon, and polyadenylation site usage in cells.
|