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Gene Information
Gene symbol: TGM2
Gene name: transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
HGNC ID: 11778
Synonyms: TGC
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CRABP1 | 1 hits |
| 2 | HLA-DQA1 | 1 hits |
| 3 | IL15 | 1 hits |
| 4 | TGM1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11851313 | As one example, antibody and T cell recognition in the intestinal auto-immune disease, coeliac disease was investigated in more detail concerning the deamidation of gamma-gliadin peptides by tissue transglutaminase 9tTG) leading to autoreactive peptides specific for HLA-DQA1*0501, DQB1*0201. |
| 2 | 16807769 | We employed RNA interference to determine the role of tissue transglutaminase II (TGase II) in motility of cancer cells. |
| 3 | 16807769 | Down-regulation of TGase II by small interfering RNA against TGase II impaired adhesion and motility of HeLa cells by decreasing phosphorylation of the protein kinase, Akt, and reactive oxygen species (ROS). |
| 4 | 20112286 | Retinoic acid-metabolizing enzyme cytochrome P450 26a1 (cyp26a1) is essential for implantation: functional study of its role in early pregnancy. |
| 5 | 20112286 | Cytochrome P450 26A1 (cyp26a1), a retinoic acid (RA)-metabolizing enzyme, is involved in VA metabolism. |
| 6 | 20112286 | Accordingly, the expression of RA-related cellular retinoic acid binding protein 1 and tissue transglutaminase was markedly increased (P < 0.05) in the uterine luminal epithelium after intrauterine injection treatments. |
| 7 | 23365209 | The disease is characterized by the presence of HLA-DQ2 and/or -DQ8 haplotypes, diverse clinical manifestations, gluten-sensitive enteropathy, and production of several autoantibodies of which endomysial, tissue transglutaminase, and deamidated gliadin peptide antibodies are considered specific. |
| 8 | 25705619 | These targets include exploration of ancient wheat if they are less immunogenic, intra-luminal digestion of gluten using prolylendopeptidases, pretreatment of whole gluten with bacterial-derived peptidase before ingestion; prevention of passage of immunogenic peptides through the tight junctions such as zonulin antagonists, Blocking of HLA-DQ2 to prevent binding of immunogenic peptides, inhibition of transglutaminase 2, immune-modulation, and induction of tolerance to gluten using gluten tolerizing vaccines, use of gluten-sequestering polymers, use of anti-inflammatory drugs (glucocorticoids, budesonides) and anti-cytokines such as anti TNF-α, and anti-interleukin-15. |