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Gene Information
Gene symbol: TH
Gene name: tyrosine hydroxylase
HGNC ID: 11782
Synonyms: DYT5b
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD8A | 1 hits |
| 2 | HLA-A | 1 hits |
| 3 | IL12A | 1 hits |
| 4 | IL2 | 1 hits |
| 5 | MAOA | 1 hits |
| 6 | NR4A2 | 1 hits |
| 7 | PTGS2 | 1 hits |
| 8 | RPS27A | 1 hits |
| 9 | SLC6A3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12393580 | We achieved this by immunization with a tyrosine hydroxylase (mTH)-based DNA vaccine, enhanced with the posttranscriptional regulatory acting RNA element (WPRE), derived from woodchuck hepatitis virus in combination with an antibody-cytokine fusion protein (ch14.18-IL-2) that targets interleukin-2 (IL-2) to the tumor microenvironment. |
| 2 | 12393580 | Thus, up-regulation of interferon-gamma (IFN-gamma) expression in CD8(+) T cells occurred only in those animals that received the mTH-WPRE vaccine plus the ch14.18-IL-2 boost. |
| 3 | 18645033 | We identified three novel mouse TH (mTH3) derived peptides with high predicted binding affinity to MHC class I antigen H2-K(k) according to the prediction program SYFPEITHI and computer modeling of epitopes into the MHC class I antigen binding groove. |
| 4 | 18645033 | This effect was clearly dependent on ubiquitin and high affinity of the mTH epitopes to MHC class I antigens. |
| 5 | 19671753 | For this purpose, we generated three DNA vaccines based on pCMV-F3Ub and pBUD-CE4.1 plasmids encoding for human (h)THcDNA (A), hTH minigene (B), and hTHcDNA in combination with the proinflammatory cytokine interleukin 12 (C), and tested prophylactic and therapeutic efficacy to suppress primary tumor growth and spontaneous metastasis. |
| 6 | 19671753 | The depletion of CD8(+)T cells completely abrogated the hTH vaccine-mediated anti-NB immune response. |
| 7 | 19671753 | For this purpose, we generated three DNA vaccines based on pCMV-F3Ub and pBUD-CE4.1 plasmids encoding for human (h)THcDNA (A), hTH minigene (B), and hTHcDNA in combination with the proinflammatory cytokine interleukin 12 (C), and tested prophylactic and therapeutic efficacy to suppress primary tumor growth and spontaneous metastasis. |
| 8 | 19671753 | The depletion of CD8(+)T cells completely abrogated the hTH vaccine-mediated anti-NB immune response. |
| 9 | 22562811 | Seven days postadrenalectomy, the thymic levels of mRNAs encoding tyrosine hydroxylase, dopamine β-hydroxylase, monoamine oxidase-A and, consequently, noradrenaline were decreased. |
| 10 | 22930493 | Genetic studies have provided the opportunity to determine which proteins link vitamin D to PD pathology, e.g., Nurr1 gene, toll-like receptor, gene related to lipid disorders, vascular endothelial factor, tyrosine hydroxylase, and angiogenin. |
| 11 | 22930493 | Vitamin D also exerts its effects on cancer through nongenomic factors, e.g., bacillus Calmette-Guerin vaccination, interleukin-10, Wntβ-catenin signaling pathways, mitogen-activated protein kinase pathways, and the reduced form of the nicotinamide adenine dinucleotide phosphate. |
| 12 | 23354599 | We found that alphα-synuclein (α-syn) antibody significantly increased, IL-4 increased and IFN-r reduced in the serum of immunized C57BL/6 mice in optimized DNA vaccine group. |
| 13 | 23354599 | The preventive immunization with optimized DNA vaccine made the motor symptoms improved significantly, the apoptosis of tyrosine hydroxylase (TH) neuron and cyclooxygenase-2 (COX-2) expression significantly decreased in MPTP model mice. |
| 14 | 23907992 | We found that a dose of 1 × 10(6) cfu BCG led to higher levels of striatal DA and DAT ligand binding (28% and 42%, respectively) in BCG-vaccinated vs. unvaccinated MPTP-treated mice, but without a significant increase in substantia nigra tyrosine hydroxylase-staining neurons. |