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Gene Information

Gene symbol: THPO

Gene name: thrombopoietin

HGNC ID: 11795

Synonyms: TPO, MPLLG

Related Genes

#	Gene Symbol	Number of hits
1	CD34	1 hits
2	IL3	1 hits
3	IL6	1 hits
4	KITLG	1 hits

Related Sentences

#	PMID	Sentence
1	15342937	Selective generation of different dendritic cell precursors from CD34+ cells by interleukin-6 and interleukin-3.
2	15342937	Several cytokines, especially stem cell factor (SCF) and FLT3-ligand (FL), have been identified as essential to produce large numbers of myeloid precursors and even to increase DC yield obtained by the action of granulocyte-macrophage colony-stimulating factor (GM-CSF) and tumor necrosis factor alpha (TNF-alpha).
3	15342937	We report here that in the absence of serum, SCF, FL, and thrombopoietin (TPO) plus interleukin-6 (IL-6) and SCF, FL, and TPO plus IL-3 were able to generate CD14+CD1a- and CD14- CD1a+ myeloid DC precursors from CD34+ cells, but IL-6 had an inhibitory effect on the generation of CD14- CD1a+ cells.
4	15342937	Both DC precursors differentiated into mature DCs by GM-CSF, IL-4, and TNF-alpha, and DCs obtained from both types of culture exhibited equal allostimulatory capacity.
5	15342937	CD1a+ DCs generated could be identified on the basis of DC-specific intracellular adhesion molecule-grabbing nonintegrin (DC-SIGN) expression, a novel C-type lectin receptor expressed on dermal DCs but not on Langerhans cells.
6	15342937	In addition, the inclusion of IL-3 to the culture medium induced the appearance of CD13- cells that differentiated into plasmacytoid DC (DC2) on the addition of TNF-alpha, allowing the identification of developmental stages of DC2.