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Gene Information
Gene symbol: TIMP2
Gene name: TIMP metallopeptidase inhibitor 2
HGNC ID: 11821
Synonyms: CSC-21K
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCL11 | 1 hits |
| 2 | CSF3 | 1 hits |
| 3 | ICAM1 | 1 hits |
| 4 | IFNG | 1 hits |
| 5 | KDR | 1 hits |
| 6 | KITLG | 1 hits |
| 7 | MMP14 | 1 hits |
| 8 | MMP2 | 1 hits |
| 9 | MMP9 | 1 hits |
| 10 | NOS2A | 1 hits |
| 11 | S100A8 | 1 hits |
| 12 | TGFA | 1 hits |
| 13 | TGFB1 | 1 hits |
| 14 | TIMP1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12139214 | The open reading frame corresponds to a putative hookworm tissue inhibitor of metalloproteases (TIMP) with 33% identity and 50% similarity to the N-terminal domain of human TIMP-2. |
| 2 | 16294321 | We compared the levels of expression of a number of molecules involved in tumor metastasis, which included transforming growth factor-beta1 (TGF-beta1), E-cadherin, matrix metalloproteinases (MMPs): MT1-MMP, MMP-2, MMP-9, their tissue inhibitors (TIMPs): TIMP-1/TIMP-2, and pro-angiogenic factors CD31, VEGF-R2, and iNOS between primary and metastatic tumors by real-time RT-PCR and immunohistochemistry. |
| 3 | 16294321 | In the metastatic tumors, levels of MT1-MMP, MMP-2, and MMP-9 were significantly elevated (P < 0.001), while levels of TIMP-1/TIMP-2 and E-cadherin were decreased (P < 0.001) compared to control or primary tumors. |
| 4 | 16294321 | Levels of CD31, VEGF-R2, and iNOS were also significantly elevated in the metastatic lesions (P < 0.001). |
| 5 | 16294321 | We compared the levels of expression of a number of molecules involved in tumor metastasis, which included transforming growth factor-beta1 (TGF-beta1), E-cadherin, matrix metalloproteinases (MMPs): MT1-MMP, MMP-2, MMP-9, their tissue inhibitors (TIMPs): TIMP-1/TIMP-2, and pro-angiogenic factors CD31, VEGF-R2, and iNOS between primary and metastatic tumors by real-time RT-PCR and immunohistochemistry. |
| 6 | 16294321 | In the metastatic tumors, levels of MT1-MMP, MMP-2, and MMP-9 were significantly elevated (P < 0.001), while levels of TIMP-1/TIMP-2 and E-cadherin were decreased (P < 0.001) compared to control or primary tumors. |
| 7 | 16294321 | Levels of CD31, VEGF-R2, and iNOS were also significantly elevated in the metastatic lesions (P < 0.001). |
| 8 | 16845627 | On the basis of changes in protein expression, we identified 6 cytokines that accurately discriminate between individuals on the basis of adverse event status: granulocyte colony-stimulating factor, stem cell factor, monokine induced by interferon-gamma (CXCL9), intercellular adhesion molecule-1, eotaxin, and tissue inhibitor of metalloproteinases-2. |
| 9 | 16995990 | [Effect of TGFbeta1 vaccine on the expression of MMP-2 and TIMP-2 in rats with liver fibrosis]. |
| 10 | 21786179 | The aim of our study was to compare the immunohistochemical expression of TIMP1 and TIMP2 between an uncontrollably invasive phenomenon (cancer) and an "in situ" process (trophoblast invasion) in an effort to assess any differential role of these molecules between these two distinct phenomena and therefore to understand better their contribution in cancer invasion and migration. |
| 11 | 25236491 | Using a S100A8/A9-negative human carcinoma cell line (KB), transfection to express S100A8 and S100A9 caused selective down-regulation of MMP-2 and inhibited in vitro invasion and migration. |
| 12 | 25236491 | Conversely, silencing of endogenous S100A8 and S100A9 expression in TR146 cells, a well-differentiated HNSCC cell line, increased MMP-2 activity and in vitro invasion and migration. |
| 13 | 25236491 | Whereas hypermethylation of CpG islands occurs frequently in HNSCC, S100A8/A9-dependent regulation of MMP-2 could not be explained by modification of the upstream promoters of MMP2 or TIMP2. |