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Gene Information
Gene symbol: TIRAP
Gene name: toll-interleukin 1 receptor (TIR) domain containing adaptor protein
HGNC ID: 17192
Synonyms: Mal, wyatt
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | HSPD1 | 1 hits |
| 2 | IL1B | 1 hits |
| 3 | IL1RAPL2 | 1 hits |
| 4 | LY96 | 1 hits |
| 5 | MYD88 | 1 hits |
| 6 | NFKB1 | 1 hits |
| 7 | TICAM1 | 1 hits |
| 8 | TICAM2 | 1 hits |
| 9 | TLR2 | 1 hits |
| 10 | TLR4 | 1 hits |
| 11 | TLR6 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15809303 | Furthermore, we show that whereas mycobacterial heat shock protein 65 signals exclusively through Toll-like receptor 4, heat shock protein 70 also signals through Toll-like receptor 2. |
| 2 | 15809303 | Mycobacterial heat shock protein 65-induced NF-kappaB activation was MyD88-, TIRAP-, TRIF-, and TRAM-dependent and required the presence of MD-2. |
| 3 | 16245793 | MyD88/TRIF double defi-indicating that innate immunity is involved in anti-mycobacterial infection. (1) SNP (single nucleotide polymorphism) analysis in association with Mycobacterium tuberculosis: Taro SHIRAKAWA (Department of Health Promotion & Human Behavior, Kyoto University Medical School, and RIKEN SRC Center) Candidate gene approach was made on 18 SNPs in 11 genes in association with M. tuberculosis. |
| 4 | 16245793 | In TLR signaling pathways, Toll/IL-1 receptor (TIR) domain-containing adaptors, such as MyD88, TIRAP, TRIF, and TRAM, have been shown to play pivotal roles. |
| 5 | 16245793 | MyD88/TRIF double deficient mice, in which TLR-dependent activation of innate immunity is abolished, showed high sensitivity to mycobacterial infection, indicating that innate immunity is critically involved in anti-mycobacterial responses. |
| 6 | 23112821 | We conducted full-exon sequencing in samples obtained from Uganda (n = 48) and South Africa (n = 48), in four genes in the TLR pathway: TLR2, TLR4, TLR6, and TIRAP. |
| 7 | 23112821 | We identified one novel TIRAP SNP (with minor allele frequency [MAF] 3.2%) and a novel TLR6 SNP (MAF 8%) in the Ugandan population, and a TLR6 SNP that is unique to the South African population (MAF 14%). |