Ignet

Gene Information

Gene symbol: TNFRSF10D

Gene name: tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain

HGNC ID: 11907

Synonyms: DcR2, TRUNDD, TRAILR4, CD264

Related Genes

#	Gene Symbol	Number of hits
1	BCL2	1 hits
2	BCL2A1	1 hits
3	CASP2	1 hits
4	CASP8	1 hits
5	CAST	1 hits
6	CCDC25	1 hits
7	CCL4	1 hits
8	CDK2	1 hits
9	CDKN1A	1 hits
10	CFLAR	1 hits
11	GADD45B	1 hits
12	IL1B	1 hits
13	MYC	1 hits
14	NFKB1	1 hits
15	NFKB2	1 hits
16	PIM2	1 hits
17	PTK2B	1 hits
18	RELA	1 hits
19	RHOBTB2	1 hits
20	SCARA3	1 hits
21	SOD2	1 hits
22	TNFAIP3	1 hits
23	TNFRSF10A	1 hits
24	TNFRSF10B	1 hits
25	TNFRSF10C	1 hits
26	TNFSF10	1 hits
27	TP53	1 hits
28	VEGFA	1 hits
29	XIAP	1 hits

Related Sentences

#	PMID	Sentence
1	10889508	Involvement of the apoptosis-mediating CD95/CD95 ligand system in MS has been demonstrated.
2	10889508	Here, we report that (auto)antigen-specific human T cells are not killed in vitro by soluble TNF-related apoptosis-inducing ligand (TRAIL) although expressing death-inducing receptors, TRAIL receptor 1 (TRAIL-R1) and TRAIL-R2.
3	10889508	The (auto)antigen-specific T cells were also resistant to specific TRAIL-R1/TRAIL-R2-directed induction of apoptosis, indicating that coexpression of the truncated TRAIL-R3 and TRAIL-R4 in these T cells is not responsible for the observed resistance.
4	10889508	In contrast to CD95, the role of TRAIL receptors in MS might not involve regulation of T cell vulnerability.
5	22986450	Specific targets in this category included genes asso-ciated with the intrinsic and extrinsic apoptotic pathways (CFLAR, TNFAIP3, TNFRSF10D, SOD2, BCL2A1, BIRC4, PIM2, TNFSF10, TNFRSF10C, CASP2 and CASP8) and genes that act via the NFĸB pathway and other mechanisms to prolong cell viability (NFKB1, NFKB2 and RELA, IL1B, CAST, CDK2,GADD45B, BCL3, BIRC3, CDK2, IL1A, PBEF1, IL6, CXCL1, CCL4 and VEGF).
6	22986450	Moreover, we demonstrate that the X-linked inhibitor of apoptosis protein remained abundant in polymorphonuclear leukocytes over 48 h of LVS infection, whereas BAX mRNA and protein were progressively downregulated.
7	26378933	In vitro analysis revealed a higher resistance to bortezomib possibly due to an altered gene expression profile caused by del(8)(p21) including genes such as TRAIL-R4, CCDC25, RHOBTB2, PTK2B, SCARA3, MYC, BCL2 and TP53.
8	26378933	Furthermore, while bortezomib sensitized MM cells without del(8)(p21) to TRAIL/APO2L mediated apoptosis, in cells with del(8)(p21) bortezomib failed to upregulate the pro-apoptotic death receptors TRAIL-R1 and TRAIL-R2 which are located on the 8p21 region.
9	26378933	Also expressing higher levels of the decoy death receptor TRAIL-R4, these cells were largely resistant to TRAIL/APO2L mediated apoptosis.
10	26378933	In vitro analysis revealed a higher resistance to bortezomib possibly due to an altered gene expression profile caused by del(8)(p21) including genes such as TRAIL-R4, CCDC25, RHOBTB2, PTK2B, SCARA3, MYC, BCL2 and TP53.
11	26378933	Furthermore, while bortezomib sensitized MM cells without del(8)(p21) to TRAIL/APO2L mediated apoptosis, in cells with del(8)(p21) bortezomib failed to upregulate the pro-apoptotic death receptors TRAIL-R1 and TRAIL-R2 which are located on the 8p21 region.
12	26378933	Also expressing higher levels of the decoy death receptor TRAIL-R4, these cells were largely resistant to TRAIL/APO2L mediated apoptosis.