Ignet

Gene Information

Gene symbol: TNFSF8

Gene name: tumor necrosis factor (ligand) superfamily, member 8

HGNC ID: 11938

Synonyms: CD153

Related Genes

#	Gene Symbol	Number of hits
1	CCL2	1 hits
2	CD27	1 hits
3	CD40LG	1 hits
4	CD70	1 hits
5	CSF1	1 hits
6	IL4	1 hits
7	PDGFB	1 hits
8	TNFRSF8	1 hits
9	TNFSF10	1 hits
10	XCL1	1 hits

Related Sentences

#	PMID	Sentence
1	9622100	Enhancement of antitumor immunity by expression of CD70 (CD27 ligand) or CD154 (CD40 ligand) costimulatory molecules in tumor cells.
2	9622100	CD70 (CD27 ligand (CD27L)), CD153 (CD30L), and CD154 (CD40L) are members of the tumor necrosis factor family of costimulatory molecules and expressed on the surface of T cells that are important for both T- and B-cell help.
3	9622100	We examined the capacity for expression of these tumor necrosis factor family members on tumor cells to induce an antitumor response either in the presence or absence of interleukin 12.
4	9622100	Retroviral vectors were constructed that expressed high levels of membrane bound CD70, CD153, or CD154 following infection and selection of the murine tumor lines MCA 207 or TS/A.
5	9622100	When tested for tumor establishment, the expression of either CD70 or CD154 was able to slow tumor growth.
6	9622100	Similarly, CD70 or CD154 were able to induce antitumor immunity at a higher frequency when tested in vaccination and therapy models.
7	9622100	CD70 was able to induce antitumor immunity at a level similar to CD80 when tested either in the presence or absence of interleukin 12.
8	9622100	Moreover, coexpression of CD70 and CD80 was able to synergize the induction of a higher frequency of antitumor immunity in a vaccination model.
9	9622100	Taken together, our results suggest that CD154 and in particular CD70 are able to contribute to the induction of the immune response to tumor in murine models and thus may be of use for human clinical trials.
10	9622100	Enhancement of antitumor immunity by expression of CD70 (CD27 ligand) or CD154 (CD40 ligand) costimulatory molecules in tumor cells.
11	9622100	CD70 (CD27 ligand (CD27L)), CD153 (CD30L), and CD154 (CD40L) are members of the tumor necrosis factor family of costimulatory molecules and expressed on the surface of T cells that are important for both T- and B-cell help.
12	9622100	We examined the capacity for expression of these tumor necrosis factor family members on tumor cells to induce an antitumor response either in the presence or absence of interleukin 12.
13	9622100	Retroviral vectors were constructed that expressed high levels of membrane bound CD70, CD153, or CD154 following infection and selection of the murine tumor lines MCA 207 or TS/A.
14	9622100	When tested for tumor establishment, the expression of either CD70 or CD154 was able to slow tumor growth.
15	9622100	Similarly, CD70 or CD154 were able to induce antitumor immunity at a higher frequency when tested in vaccination and therapy models.
16	9622100	CD70 was able to induce antitumor immunity at a level similar to CD80 when tested either in the presence or absence of interleukin 12.
17	9622100	Moreover, coexpression of CD70 and CD80 was able to synergize the induction of a higher frequency of antitumor immunity in a vaccination model.
18	9622100	Taken together, our results suggest that CD154 and in particular CD70 are able to contribute to the induction of the immune response to tumor in murine models and thus may be of use for human clinical trials.
19	22087247	Results showed that SIS affected cytokine and chemokines microenvironments such as up-regulation of IL-4 and CD30-ligand and activation of chemotactic factors LIX and KC (neutrophil chemotactic factors), MCP-1 (monocytes chemotactic factors), MIP 1-α (macrophage chemotactic factor) and lymphotactin, as well as, growth factors like M-CSF.
20	22087247	However, in contrast to alum, SIS had no effects on pro-inflammatory cytokines (IL-6, IL-1β, TNF-α) or NLRP3, but it appeared to promote both Th1 and Th2 responses under different conditions.