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Gene Information
Gene symbol: TOP1
Gene name: topoisomerase (DNA) I
HGNC ID: 11986
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD4 | 1 hits |
| 2 | GAST | 1 hits |
| 3 | TYMS | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11536152 | T cells rendered anergic lost IL-2 production but produced IFN-gamma and IL-10 upon stimulation. |
| 2 | 11536152 | Autoreactive CD4(+) T cell clones specific for topoisomerase I derived from a patient with scleroderma were also rendered anergic after co-culture with topoisomerase I-pulsed autologous pDC2,resulting in failure to proliferate or provide help to B cells. |
| 3 | 12409652 | These agents include the thymidylate synthase inhibitor capecitabine (which is possibly activated at the tumor site), the antigastrin immunogen G17DT (which is an immunization designed to neutralize the pancreatic growth factor gastrin), and the topoisomerase I inhibitor 9-nitrocamptothecin. |