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Gene Information
Gene symbol: TOP2B
Gene name: topoisomerase (DNA) II beta 180kDa
HGNC ID: 11990
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CSF2 | 1 hits |
| 2 | IFNG | 1 hits |
| 3 | IL10 | 1 hits |
| 4 | IL2 | 1 hits |
| 5 | RARA | 1 hits |
| 6 | RARB | 1 hits |
| 7 | RARG | 1 hits |
| 8 | TNF | 1 hits |
| 9 | VDR | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19902255 | Twenty-two significant associations (range of P values 0.002-0.048) were found between SNPs in the vitamin A receptor family (RARA, RARB, TOP2B and RARG), vitamin D receptor and downstream mediator of vitamin D signaling (RXRA) genes and rubella virus-specific (IFN-gamma, IL-2, IL-10, TNF-alpha, and GM-CSF) cytokine immune responses. |
| 2 | 19902255 | A TLR3 gene promoter region SNP (rs5743305, -8441A > T) was associated with rubella-specific GM-CSF secretion. |
| 3 | 19902255 | Importantly, SNPs in the TRIM5 gene coding regions, rs3740996 (His43Tyr) and rs10838525 (Gln136Arg), were associated with an allele dose-related secretion of rubella virus-specific TNF-alpha and IL-2/GM-CSF, respectively, and have been previously shown to have functional consequences regarding the antiviral activity and susceptibility to HIV-1 infection. |
| 4 | 19902255 | We identified associations between individual SNPs and haplotypes in, or involving, the RIG-I (DDX58) gene and rubella-specific TNF-alpha secretion. |