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Gene Information

Gene symbol: TSC2

Gene name: tuberous sclerosis 2

HGNC ID: 12363

Synonyms: tuberin, LAM

Related Genes

#	Gene Symbol	Number of hits
1	CD8A	1 hits
2	CRTC1	1 hits

Related Sentences

#	PMID	Sentence
1	25893604	mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation.
2	25893604	Herein, we show that mTOR complex 1 (mTORC1) and mTORC2 have distinct roles in the generation of CD8+ T cell effector and memory populations.
3	25893604	Evaluation of mice with a T cell-specific deletion of the gene encoding the negative regulator of mTORC1, tuberous sclerosis complex 2 (TSC2), resulted in the generation of highly glycolytic and potent effector CD8+ T cells; however, due to constitutive mTORC1 activation, these cells retained a terminally differentiated effector phenotype and were incapable of transitioning into a memory state.
4	25893604	In contrast, CD8+ T cells deficient in mTORC1 activity due to loss of RAS homolog enriched in brain (RHEB) failed to differentiate into effector cells but retained memory characteristics, such as surface marker expression, a lower metabolic rate, and increased longevity.
5	25893604	While mTORC1 influenced CD8+ T cell effector responses, mTORC2 activity regulated CD8+ T cell memory. mTORC2 inhibition resulted in metabolic reprogramming, which enhanced the generation of CD8+ memory cells.
6	25893604	Overall, these results define specific roles for mTORC1 and mTORC2 that link metabolism and CD8+ T cell effector and memory generation and suggest that these functions have the potential to be targeted for enhancing vaccine efficacy and antitumor immunity.