- About
- Home
- Introduction
- Statistics
- Programs
- Dignet
- Gene
- GenePair
- BioSummarAI
- Help & Docs
- Documents
- Help
- FAQs
- Links
- Acknowledge
- Disclaimer
- Contact Us
Gene Information
Gene symbol: TYROBP
Gene name: TYRO protein tyrosine kinase binding protein
HGNC ID: 12449
Synonyms: DAP12, PLO-SL, KARAP
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CARD9 | 1 hits |
| 2 | MYD88 | 1 hits |
| 3 | NLRP3 | 1 hits |
| 4 | SYK | 1 hits |
| 5 | TREM2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 24806599 | Here we show that the coupling of ITAM-Syk-CARD9 signalling to interleukin-1 (IL-1) secretion in DCs is crucial for allergic sensitization to haptens. |
| 2 | 24806599 | Both MyD88 and Caspase recruitment domain-containing protein 9 (CARD9) signalling are required for contact hypersensitivity (CHS). |
| 3 | 24806599 | Naïve T cells require signals received through IL-1R1-MyD88 for effector differentiation, whereas DCs require CARD9 and spleen tyrosine kinase (Syk) signalling for hapten-induced IL-1α/β secretion and their ability to prime T cells. |
| 4 | 24806599 | DC-specific deletion of CARD9, DAP12, Syk or NLRP3, but not MyD88, is sufficient to abolish CHS. |
| 5 | 24806599 | All tested haptens, but not irritants, can induce Syk activation, leading to both the CARD9/BCL10-dependent pro-IL-1 synthesis (signal1) and reactive oxygen species-mediated NLRP3 inflammasome activation (signal2), required for IL-1 secretion. |
| 6 | 26021803 | Evidence for TLR4 and FcRγ-CARD9 activation by cholera toxin B subunit and its direct bindings to TREM2 and LMIR5 receptors. |
| 7 | 26021803 | Indeed, CTX-induced IL-6 production was substantially reduced in MyD88(-/-) or TLR4(-/-) macrophages. |
| 8 | 26021803 | CTB targeted not only GM1 and TLR4 but also TREM2 and LMIR5/CD300b. |
| 9 | 26021803 | CTB-TREM2 interaction initiated signal transduction through adaptor protein DAP12. |
| 10 | 26021803 | In summary, CTB targets TLR4, FcRγ-CARD9, TREM2, and LMIR5. |