Ignet

Gene Information

Gene symbol: VIP

Gene name: vasoactive intestinal peptide

HGNC ID: 12693

Related Genes

#	Gene Symbol	Number of hits
1	ADCYAP1	1 hits
2	GNRH1	1 hits
3	IL12A	1 hits
4	NPY	1 hits
5	TGFB1	1 hits

Related Sentences

#	PMID	Sentence
1	10542221	Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit interleukin-12 transcription by regulating nuclear factor kappaB and Ets activation.
2	10542221	The vasoactive intestinal peptide (VIP) and the structurally related neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) act as "macrophage-deactivating factors".
3	10542221	We showed previously that VIP and PACAP inhibit the production of macrophage-derived tumor necrosis factor-alpha, interleukin (IL)-6, nitric oxide, and IL-12.
4	10542221	This study examines the molecular mechanisms involved in the VIP/PACAP inhibition of IL-12 production.
5	10542221	VIP and PACAP inhibit IL-12 (p40) gene expression by affecting both NF-kappaB binding and the composition of the Ets-2 binding complex.
6	10542221	Both neuropeptides prevent the activation-induced nuclear translocation of the NF-kappaB components p65 and c-Rel by inhibiting the reduction in cytoplasmic IkappaBalpha.
7	10542221	Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit interleukin-12 transcription by regulating nuclear factor kappaB and Ets activation.
8	10542221	The vasoactive intestinal peptide (VIP) and the structurally related neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) act as "macrophage-deactivating factors".
9	10542221	We showed previously that VIP and PACAP inhibit the production of macrophage-derived tumor necrosis factor-alpha, interleukin (IL)-6, nitric oxide, and IL-12.
10	10542221	This study examines the molecular mechanisms involved in the VIP/PACAP inhibition of IL-12 production.
11	10542221	VIP and PACAP inhibit IL-12 (p40) gene expression by affecting both NF-kappaB binding and the composition of the Ets-2 binding complex.
12	10542221	Both neuropeptides prevent the activation-induced nuclear translocation of the NF-kappaB components p65 and c-Rel by inhibiting the reduction in cytoplasmic IkappaBalpha.
13	11534784	Influence of active immunization against GnRH on VIP- and NPY-positive innervation of the porcine testis.
14	11534784	The influence of an anti-GnRH vaccine on VIP- and NPY-positive innervation of testes was studied in the pig.
15	11534784	The immunization prevented the occurrence of changes in the pattern of VIP- and NPY-positive testicular innervation associated with the sexual maturation: it maintained the density of innervation at the high level characteristic for sexually immature animals.
16	11534784	The studies on VIP and NPY concentration in the testicular tissue with radioimmunoassay (RIA) revealed immunization-dependent changes in the peptide concentration, however, some discrepancies between morphological changes and peptide levels were observed.
17	11534784	Influence of active immunization against GnRH on VIP- and NPY-positive innervation of the porcine testis.
18	11534784	The influence of an anti-GnRH vaccine on VIP- and NPY-positive innervation of testes was studied in the pig.
19	11534784	The immunization prevented the occurrence of changes in the pattern of VIP- and NPY-positive testicular innervation associated with the sexual maturation: it maintained the density of innervation at the high level characteristic for sexually immature animals.
20	11534784	The studies on VIP and NPY concentration in the testicular tissue with radioimmunoassay (RIA) revealed immunization-dependent changes in the peptide concentration, however, some discrepancies between morphological changes and peptide levels were observed.
21	11534784	Influence of active immunization against GnRH on VIP- and NPY-positive innervation of the porcine testis.
22	11534784	The influence of an anti-GnRH vaccine on VIP- and NPY-positive innervation of testes was studied in the pig.
23	11534784	The immunization prevented the occurrence of changes in the pattern of VIP- and NPY-positive testicular innervation associated with the sexual maturation: it maintained the density of innervation at the high level characteristic for sexually immature animals.
24	11534784	The studies on VIP and NPY concentration in the testicular tissue with radioimmunoassay (RIA) revealed immunization-dependent changes in the peptide concentration, however, some discrepancies between morphological changes and peptide levels were observed.
25	11534784	Influence of active immunization against GnRH on VIP- and NPY-positive innervation of the porcine testis.
26	11534784	The influence of an anti-GnRH vaccine on VIP- and NPY-positive innervation of testes was studied in the pig.
27	11534784	The immunization prevented the occurrence of changes in the pattern of VIP- and NPY-positive testicular innervation associated with the sexual maturation: it maintained the density of innervation at the high level characteristic for sexually immature animals.
28	11534784	The studies on VIP and NPY concentration in the testicular tissue with radioimmunoassay (RIA) revealed immunization-dependent changes in the peptide concentration, however, some discrepancies between morphological changes and peptide levels were observed.
29	15922114	Autoimmune dysfunction of certain vasoactive neuropeptides (e.g., vasoactive intestinal peptide, pituitary adenylate cyclase activating polypeptide) may be implicated in a range of disorders associated with fatigue-like states (chronic fatigue syndrome, Gulf War syndrome) and even sudden infant death syndrome (SIDS).
30	21074276	Regulation of IgA production in cattle is not completely understood and thus we have focused in part on highly conserved factors such as transforming growth factor beta, Type I and Type 2 interferons, neuropeptides which interdigitate mucosal tissues (vasoactive intestinal peptide or VIP), and a small peptide (IgA inducing peptide or IGIP) which can serve as targets for modulation and increasing SIgA virus-specific antibodies.
31	21074276	In previous studies in cattle, IgA has been shown to be regulated by several cytokines including IFN-gamma, Type I interferons such as IFN-alpha and IFN-tau, transforming growth factor beta, IgA inducing peptide and other potential factors such as APRIL and BlyS which have not yet been fully evaluated in cattle.
32	21074276	Many of these factors, namely TGF-beta and Type I interferons block cell cycle progression which is an essential component of Ig class switching and thus these factors require additional regulatory factors such as IL-2 to drive cells through cell cycle resulting in class switch recombination.