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Gene Information
Gene symbol: WEE1
Gene name: WEE1 homolog (S. pombe)
HGNC ID: 12761
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCNB1 | 1 hits |
| 2 | CDC2 | 1 hits |
| 3 | CDC25C | 1 hits |
| 4 | CHEK1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21525341 | We then showed that the activity of the Cdc2-cyclin B1 complex was significantly decreased in HHV-6A-infected HSB-2 cells. |
| 2 | 21525341 | Furthermore, we found that inactivation of Cdc2-cyclin B1 in HHV-6A-infected cells occurred through the inhibitory Tyr15 phosphorylation resulting from elevated Wee1 expression and inactivated Cdc25C. |
| 3 | 21525341 | The reduction of Cdc2-cyclin B1 activity in HHV-6-infected cells was also partly due to the increased expression of the cell cycle-regulatory molecule p21 in a p53-dependent manner. |
| 4 | 21525341 | In addition, HHV-6A infection activated the DNA damage checkpoint kinases Chk2 and Chk1. |
| 5 | 25458954 | The selective Wee1 inhibitor MK-1775 has demonstrated promising results when combined with DNA damaging agents, and more recently with CHK1 inhibitors in various malignancies. |
| 6 | 25458954 | We demonstrate that MK-1775 treatment results in increased H2AX phosphorylation, indicating increased DNA double-strand breaks, and activation of CHK1, which are both dependent on CDK activity. |