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Gene Information
Gene symbol: YWHAQ
Gene name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
HGNC ID: 12854
Synonyms: HS1, 14-3-3
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | APLP2 | 1 hits |
| 2 | APP | 1 hits |
| 3 | MAPT | 1 hits |
| 4 | PIN1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19482462 | More recently, alternative approaches have begun to target the microtubule binding protein tau, a component of neurofibrillary tangles. |
| 2 | 20980799 | The aggregation and accumulation of the microtubule-associated protein (Tau) is a pathological hallmark of Alzheimer's disease (AD) and many neurodegenerative diseases. |
| 3 | 22461630 | Aggregation of the microtubule associated protein Tau is associated with several neurodegenerative disorders, including Alzheimer disease and frontotemporal dementia. |
| 4 | 23977276 | The unmet need of effective therapy for Alzheimer's disease, combined with problematic pharmacological approaches, led the field to explore immunotherapy, first against amyloid peptides and recently against protein Tau. |
| 5 | 23977276 | Here we adapted the liposome-based amyloid vaccine that proved safe and efficacious, and incorporated a synthetic phosphorylated peptide to mimic the important phospho-epitope of protein Tau at residues pS396/pS404. |
| 6 | 23977276 | The unmet need of effective therapy for Alzheimer's disease, combined with problematic pharmacological approaches, led the field to explore immunotherapy, first against amyloid peptides and recently against protein Tau. |
| 7 | 23977276 | Here we adapted the liposome-based amyloid vaccine that proved safe and efficacious, and incorporated a synthetic phosphorylated peptide to mimic the important phospho-epitope of protein Tau at residues pS396/pS404. |
| 8 | 24534472 | In AD, Pin1 affects two proteins thought to be key to disease pathology: the amyloid precursor protein (APP) and the microtubule-binding protein tau, by switching them from a dysfunctional shape (cis) back to a functional one (trans), which can be distinguished by cis and trans-specific antibodies. |
| 9 | 24534472 | In the brains of people with AD, Pin1 is absent or inactivated and cis tau is accumulated at early stages of AD. |
| 10 | 24534472 | In the absence of Pin1, APP is processed into toxic beta-amyloid and tau becomes misshapen to form tangles. |