# |
PMID |
Sentence |
1 |
2574188
|
The earliest TH defect is the loss of responses to FLU and TET, indicating a selective defect in CD4+ MHC self-restricted TH function.
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2 |
2574188
|
The later loss of ALLO and PHA IL-2 responses suggests more severe TH dysfunction involving both CD4+ and CD8+ T cells.
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3 |
10958921
|
FLU-induced proliferation and IFN-gamma levels of elderly were lower than young before and after immunization.
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4 |
10958921
|
FLU-induced IL-6 and IL-10 levels did not change after immunization of either group.
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5 |
10958921
|
FLU-induced proliferation and IFN-gamma levels of elderly were lower than young before and after immunization.
|
6 |
10958921
|
FLU-induced IL-6 and IL-10 levels did not change after immunization of either group.
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7 |
16260072
|
Both PHA- and FLU-induced proliferation were reduced in elderly subgroups.
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8 |
16260072
|
IL-2 and IFN-gamma levels did not change after vaccination of elderly, regardless of race.
|
9 |
17121795
|
In this study, we have established that a vaccine platform based on the coat protein of papaya mosaic virus (PapMV CP), previously shown to induce a humoral response, can induce major histocompatibility complex (MHC) class I cross-presentation of HLA-A*0201 epitopes from gp100, a melanoma antigen, and from influenza virus M1 matrix protein.
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10 |
17121795
|
When we pulsed HLA-A*0201+ antigen-presenting cells (APCs) with the recombinant PapMV FLU or gp100, we noted that antigen-specific CD8+ T cells were highly reactive to these APCs, demonstrating that the epitope from the VLPs were processed and loaded on the MHC class I complex.
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11 |
24291199
|
By analyzing the differentiation state of IFN-γ-secreting CD8(+) T cells, we found a CCR7(-)CD45RA(-)CD28(+int)/CD28(-) profile (>85%) belonging to a subset of intermediate-differentiated effector T cells for HIV, FLU, and EBV.
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12 |
24291199
|
The percentage of single IFN-γ T cell producers in response to HIV was 62% of the total of secreting T cells compared with 35% for FLU and EBV, dual and triple (IFN-γ/IL-2/CD107a) T cell producers could also be detected but at lower levels (8% compared with 37%).
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