Ignet

Gene Information

Gene symbol: FGF2

Gene name: fibroblast growth factor 2 (basic)

HGNC ID: 3676

Related Genes

#	Gene Symbol	Number of hits
1	DES	1 hits
2	FGF10	1 hits
3	FGF7	1 hits
4	FGFR2	1 hits
5	INS	1 hits
6	MSN	1 hits
7	NUDT6	1 hits
8	PDGFA	1 hits
9	PDGFB	1 hits
10	RDX	1 hits

Related Sentences

#	PMID	Sentence
1	8200474	Analysis of the fibroblast growth factor-2 (FGF-2 or bFGF) proteins during chicken embryonic pattern formation and organogenesis revealed that three isoforms (18.5, 20.0, and 21.5 kDa) were synthesized by alternative translation initiation from one coding region.
2	8647942	The cytoskeletal linking proteins, moesin and radixin, are upregulated by platelet-derived growth factor, but not basic fibroblast growth factor in experimental mesangial proliferative glomerulonephritis.
3	8647942	The expression of the two cytoskeletal linking proteins, moesin and radixin, was examined in experimental mesangial proliferative nephritis in rats (anti-Thy1 model).
4	8647942	Moesin and radixin mRNA and protein are constitutively expressed in all cell types of normal rat glomeruli, except podocytes.
5	8647942	In the anti-Thy1 model the expression of moesin and radixin was increased in infiltrating macrophages and in activated, alpha-smooth muscle actin-positive mesangial cells and was concentrated in the cellular extensions of mesangial cells in areas of glomerular remodelling.
6	8647942	Studies using neutralizing antibodies demonstrated that the increase in moesin and radixin expression by mesangial cells is mediated by PDGF, but not bFGF.
7	8647942	The increase in these cytoskeletal proteins appears to be regulated primarily (radixin) or partially (moesin) posttranscriptionally.
8	8647942	The data suggest that PDGF mediated upregulation of the cytoskeletal proteins, moesin and radixin, is important for cell migration and other changes that accompany the coordinated restoration of glomerular architecture after injury.
9	8995747	Changes in glomerular epithelial cells induced by FGF2 and FGF2 neutralizing antibody in puromycin aminonucleoside nephropathy.
10	8995747	In the present study, two series of experiments were done with PAN nephropathy rats given fibroblast growth factor 2 (FGF2) or FGF2 neutralizing antibodies.
11	8995747	In the first series of experiments, a dose of 10 micrograms of FGF2 (FGF2 group), 40 micrograms of an FGF2 neutralizing antibody (Anti-FGF2 group) or an equal volume of physiological saline (Control group) was administered for four days after PAN injection.
12	8995747	Urinary protein increased more in the FGF2 group than in the other two groups.
13	8995747	PCNA (+) glomerular cells were found in decreasing order in groups FGF2, Control and Anti-FGF2.
14	8995747	Staining for desmin, a marker of podocyte injury, was significantly reduced in the Anti-FGF2 group.
15	8995747	Glomerular adhesive lesions were found in decreasing order in groups FGF2, Control and Anti-FGF2.
16	8995747	The second series of experiments was designed to study the effects of FGF2 neutralizing antibody (40 micrograms for 5 days after PAN injection, in MoAb group) on severely damaged podocytes caused by repeated (two courses) injections in the PAN nephropathy rats.
17	8995747	It was supposed that FGF2 would promote the formation of adhesive lesions by stimulating the proliferation of podocytes and epithelial cells of Bowman's capsule.
18	8995747	Additionally, FGF2 itself was thought to impair podocytes because of the increasing desmin score and proteinuria.
19	8995747	Changes in glomerular epithelial cells induced by FGF2 and FGF2 neutralizing antibody in puromycin aminonucleoside nephropathy.
20	8995747	In the present study, two series of experiments were done with PAN nephropathy rats given fibroblast growth factor 2 (FGF2) or FGF2 neutralizing antibodies.
21	8995747	In the first series of experiments, a dose of 10 micrograms of FGF2 (FGF2 group), 40 micrograms of an FGF2 neutralizing antibody (Anti-FGF2 group) or an equal volume of physiological saline (Control group) was administered for four days after PAN injection.
22	8995747	Urinary protein increased more in the FGF2 group than in the other two groups.
23	8995747	PCNA (+) glomerular cells were found in decreasing order in groups FGF2, Control and Anti-FGF2.
24	8995747	Staining for desmin, a marker of podocyte injury, was significantly reduced in the Anti-FGF2 group.
25	8995747	Glomerular adhesive lesions were found in decreasing order in groups FGF2, Control and Anti-FGF2.
26	8995747	The second series of experiments was designed to study the effects of FGF2 neutralizing antibody (40 micrograms for 5 days after PAN injection, in MoAb group) on severely damaged podocytes caused by repeated (two courses) injections in the PAN nephropathy rats.
27	8995747	It was supposed that FGF2 would promote the formation of adhesive lesions by stimulating the proliferation of podocytes and epithelial cells of Bowman's capsule.
28	8995747	Additionally, FGF2 itself was thought to impair podocytes because of the increasing desmin score and proteinuria.
29	8995747	Changes in glomerular epithelial cells induced by FGF2 and FGF2 neutralizing antibody in puromycin aminonucleoside nephropathy.
30	8995747	In the present study, two series of experiments were done with PAN nephropathy rats given fibroblast growth factor 2 (FGF2) or FGF2 neutralizing antibodies.
31	8995747	In the first series of experiments, a dose of 10 micrograms of FGF2 (FGF2 group), 40 micrograms of an FGF2 neutralizing antibody (Anti-FGF2 group) or an equal volume of physiological saline (Control group) was administered for four days after PAN injection.
32	8995747	Urinary protein increased more in the FGF2 group than in the other two groups.
33	8995747	PCNA (+) glomerular cells were found in decreasing order in groups FGF2, Control and Anti-FGF2.
34	8995747	Staining for desmin, a marker of podocyte injury, was significantly reduced in the Anti-FGF2 group.
35	8995747	Glomerular adhesive lesions were found in decreasing order in groups FGF2, Control and Anti-FGF2.
36	8995747	The second series of experiments was designed to study the effects of FGF2 neutralizing antibody (40 micrograms for 5 days after PAN injection, in MoAb group) on severely damaged podocytes caused by repeated (two courses) injections in the PAN nephropathy rats.
37	8995747	It was supposed that FGF2 would promote the formation of adhesive lesions by stimulating the proliferation of podocytes and epithelial cells of Bowman's capsule.
38	8995747	Additionally, FGF2 itself was thought to impair podocytes because of the increasing desmin score and proteinuria.
39	8995747	Changes in glomerular epithelial cells induced by FGF2 and FGF2 neutralizing antibody in puromycin aminonucleoside nephropathy.
40	8995747	In the present study, two series of experiments were done with PAN nephropathy rats given fibroblast growth factor 2 (FGF2) or FGF2 neutralizing antibodies.
41	8995747	In the first series of experiments, a dose of 10 micrograms of FGF2 (FGF2 group), 40 micrograms of an FGF2 neutralizing antibody (Anti-FGF2 group) or an equal volume of physiological saline (Control group) was administered for four days after PAN injection.
42	8995747	Urinary protein increased more in the FGF2 group than in the other two groups.
43	8995747	PCNA (+) glomerular cells were found in decreasing order in groups FGF2, Control and Anti-FGF2.
44	8995747	Staining for desmin, a marker of podocyte injury, was significantly reduced in the Anti-FGF2 group.
45	8995747	Glomerular adhesive lesions were found in decreasing order in groups FGF2, Control and Anti-FGF2.
46	8995747	The second series of experiments was designed to study the effects of FGF2 neutralizing antibody (40 micrograms for 5 days after PAN injection, in MoAb group) on severely damaged podocytes caused by repeated (two courses) injections in the PAN nephropathy rats.
47	8995747	It was supposed that FGF2 would promote the formation of adhesive lesions by stimulating the proliferation of podocytes and epithelial cells of Bowman's capsule.
48	8995747	Additionally, FGF2 itself was thought to impair podocytes because of the increasing desmin score and proteinuria.
49	8995747	Changes in glomerular epithelial cells induced by FGF2 and FGF2 neutralizing antibody in puromycin aminonucleoside nephropathy.
50	8995747	In the present study, two series of experiments were done with PAN nephropathy rats given fibroblast growth factor 2 (FGF2) or FGF2 neutralizing antibodies.
51	8995747	In the first series of experiments, a dose of 10 micrograms of FGF2 (FGF2 group), 40 micrograms of an FGF2 neutralizing antibody (Anti-FGF2 group) or an equal volume of physiological saline (Control group) was administered for four days after PAN injection.
52	8995747	Urinary protein increased more in the FGF2 group than in the other two groups.
53	8995747	PCNA (+) glomerular cells were found in decreasing order in groups FGF2, Control and Anti-FGF2.
54	8995747	Staining for desmin, a marker of podocyte injury, was significantly reduced in the Anti-FGF2 group.
55	8995747	Glomerular adhesive lesions were found in decreasing order in groups FGF2, Control and Anti-FGF2.
56	8995747	The second series of experiments was designed to study the effects of FGF2 neutralizing antibody (40 micrograms for 5 days after PAN injection, in MoAb group) on severely damaged podocytes caused by repeated (two courses) injections in the PAN nephropathy rats.
57	8995747	It was supposed that FGF2 would promote the formation of adhesive lesions by stimulating the proliferation of podocytes and epithelial cells of Bowman's capsule.
58	8995747	Additionally, FGF2 itself was thought to impair podocytes because of the increasing desmin score and proteinuria.
59	8995747	Changes in glomerular epithelial cells induced by FGF2 and FGF2 neutralizing antibody in puromycin aminonucleoside nephropathy.
60	8995747	In the present study, two series of experiments were done with PAN nephropathy rats given fibroblast growth factor 2 (FGF2) or FGF2 neutralizing antibodies.
61	8995747	In the first series of experiments, a dose of 10 micrograms of FGF2 (FGF2 group), 40 micrograms of an FGF2 neutralizing antibody (Anti-FGF2 group) or an equal volume of physiological saline (Control group) was administered for four days after PAN injection.
62	8995747	Urinary protein increased more in the FGF2 group than in the other two groups.
63	8995747	PCNA (+) glomerular cells were found in decreasing order in groups FGF2, Control and Anti-FGF2.
64	8995747	Staining for desmin, a marker of podocyte injury, was significantly reduced in the Anti-FGF2 group.
65	8995747	Glomerular adhesive lesions were found in decreasing order in groups FGF2, Control and Anti-FGF2.
66	8995747	The second series of experiments was designed to study the effects of FGF2 neutralizing antibody (40 micrograms for 5 days after PAN injection, in MoAb group) on severely damaged podocytes caused by repeated (two courses) injections in the PAN nephropathy rats.
67	8995747	It was supposed that FGF2 would promote the formation of adhesive lesions by stimulating the proliferation of podocytes and epithelial cells of Bowman's capsule.
68	8995747	Additionally, FGF2 itself was thought to impair podocytes because of the increasing desmin score and proteinuria.
69	8995747	Changes in glomerular epithelial cells induced by FGF2 and FGF2 neutralizing antibody in puromycin aminonucleoside nephropathy.
70	8995747	In the present study, two series of experiments were done with PAN nephropathy rats given fibroblast growth factor 2 (FGF2) or FGF2 neutralizing antibodies.
71	8995747	In the first series of experiments, a dose of 10 micrograms of FGF2 (FGF2 group), 40 micrograms of an FGF2 neutralizing antibody (Anti-FGF2 group) or an equal volume of physiological saline (Control group) was administered for four days after PAN injection.
72	8995747	Urinary protein increased more in the FGF2 group than in the other two groups.
73	8995747	PCNA (+) glomerular cells were found in decreasing order in groups FGF2, Control and Anti-FGF2.
74	8995747	Staining for desmin, a marker of podocyte injury, was significantly reduced in the Anti-FGF2 group.
75	8995747	Glomerular adhesive lesions were found in decreasing order in groups FGF2, Control and Anti-FGF2.
76	8995747	The second series of experiments was designed to study the effects of FGF2 neutralizing antibody (40 micrograms for 5 days after PAN injection, in MoAb group) on severely damaged podocytes caused by repeated (two courses) injections in the PAN nephropathy rats.
77	8995747	It was supposed that FGF2 would promote the formation of adhesive lesions by stimulating the proliferation of podocytes and epithelial cells of Bowman's capsule.
78	8995747	Additionally, FGF2 itself was thought to impair podocytes because of the increasing desmin score and proteinuria.
79	8995747	Changes in glomerular epithelial cells induced by FGF2 and FGF2 neutralizing antibody in puromycin aminonucleoside nephropathy.
80	8995747	In the present study, two series of experiments were done with PAN nephropathy rats given fibroblast growth factor 2 (FGF2) or FGF2 neutralizing antibodies.
81	8995747	In the first series of experiments, a dose of 10 micrograms of FGF2 (FGF2 group), 40 micrograms of an FGF2 neutralizing antibody (Anti-FGF2 group) or an equal volume of physiological saline (Control group) was administered for four days after PAN injection.
82	8995747	Urinary protein increased more in the FGF2 group than in the other two groups.
83	8995747	PCNA (+) glomerular cells were found in decreasing order in groups FGF2, Control and Anti-FGF2.
84	8995747	Staining for desmin, a marker of podocyte injury, was significantly reduced in the Anti-FGF2 group.
85	8995747	Glomerular adhesive lesions were found in decreasing order in groups FGF2, Control and Anti-FGF2.
86	8995747	The second series of experiments was designed to study the effects of FGF2 neutralizing antibody (40 micrograms for 5 days after PAN injection, in MoAb group) on severely damaged podocytes caused by repeated (two courses) injections in the PAN nephropathy rats.
87	8995747	It was supposed that FGF2 would promote the formation of adhesive lesions by stimulating the proliferation of podocytes and epithelial cells of Bowman's capsule.
88	8995747	Additionally, FGF2 itself was thought to impair podocytes because of the increasing desmin score and proteinuria.
89	8995747	Changes in glomerular epithelial cells induced by FGF2 and FGF2 neutralizing antibody in puromycin aminonucleoside nephropathy.
90	8995747	In the present study, two series of experiments were done with PAN nephropathy rats given fibroblast growth factor 2 (FGF2) or FGF2 neutralizing antibodies.
91	8995747	In the first series of experiments, a dose of 10 micrograms of FGF2 (FGF2 group), 40 micrograms of an FGF2 neutralizing antibody (Anti-FGF2 group) or an equal volume of physiological saline (Control group) was administered for four days after PAN injection.
92	8995747	Urinary protein increased more in the FGF2 group than in the other two groups.
93	8995747	PCNA (+) glomerular cells were found in decreasing order in groups FGF2, Control and Anti-FGF2.
94	8995747	Staining for desmin, a marker of podocyte injury, was significantly reduced in the Anti-FGF2 group.
95	8995747	Glomerular adhesive lesions were found in decreasing order in groups FGF2, Control and Anti-FGF2.
96	8995747	The second series of experiments was designed to study the effects of FGF2 neutralizing antibody (40 micrograms for 5 days after PAN injection, in MoAb group) on severely damaged podocytes caused by repeated (two courses) injections in the PAN nephropathy rats.
97	8995747	It was supposed that FGF2 would promote the formation of adhesive lesions by stimulating the proliferation of podocytes and epithelial cells of Bowman's capsule.
98	8995747	Additionally, FGF2 itself was thought to impair podocytes because of the increasing desmin score and proteinuria.
99	10469357	Localization of fibroblast growth factor-2 (basic FGF) and FGF receptor-1 in adult human kidney.
100	10482316	Augmentation of kidney injury by basic fibroblast growth factor or platelet-derived growth factor does not induce progressive diabetic nephropathy in the Goto Kakizaki model of non-insulin-dependent diabetes.
101	10482316	Specifically, we examined whether the administration of either platelet-derived growth factor (PDGF) or basic fibroblast growth factor (bFGF) in sub-nephritogenic doses might lead to an aggravation of kidney structural changes associated with hyperglycemia, resulting in progressive kidney damage in the Goto Kakizaki (GK) rat, which is a genetic model of non-obese non-insulin-dependent diabetes mellitus (NIDDM), in which progressive kidney disease does not develop spontaneously.
102	10482316	The results demonstrate that the administration of PDGF to hyperglycemic GK rats led to acute mesangial cell proliferation and activation as assessed by 5-bromo-2'-deoxyuridine-positive nuclei and immunostaining for alpha-smooth muscle actin.
103	10482316	Augmentation of kidney injury by basic fibroblast growth factor or platelet-derived growth factor does not induce progressive diabetic nephropathy in the Goto Kakizaki model of non-insulin-dependent diabetes.
104	10482316	Specifically, we examined whether the administration of either platelet-derived growth factor (PDGF) or basic fibroblast growth factor (bFGF) in sub-nephritogenic doses might lead to an aggravation of kidney structural changes associated with hyperglycemia, resulting in progressive kidney damage in the Goto Kakizaki (GK) rat, which is a genetic model of non-obese non-insulin-dependent diabetes mellitus (NIDDM), in which progressive kidney disease does not develop spontaneously.
105	10482316	The results demonstrate that the administration of PDGF to hyperglycemic GK rats led to acute mesangial cell proliferation and activation as assessed by 5-bromo-2'-deoxyuridine-positive nuclei and immunostaining for alpha-smooth muscle actin.
106	11591823	To examine the potential role of fibroblast growth factor (FGF) signalling during cell differentiation, we used conditionally immortalised podocyte cells isolated from kidneys of Fgf2 mutant and wild-type mice.
107	11591823	Wild-type mouse podocyte cells upregulate FGF2 expression when differentiating in culture, as do maturing podocytes in vivo.
108	11591823	Molecular analysis of Fgf2 mutant mouse podocyte cells reveals a general disruption of FGF signalling as expression of Fgf7 and Fgf10 are also downregulated.
109	11591823	To examine the potential role of fibroblast growth factor (FGF) signalling during cell differentiation, we used conditionally immortalised podocyte cells isolated from kidneys of Fgf2 mutant and wild-type mice.
110	11591823	Wild-type mouse podocyte cells upregulate FGF2 expression when differentiating in culture, as do maturing podocytes in vivo.
111	11591823	Molecular analysis of Fgf2 mutant mouse podocyte cells reveals a general disruption of FGF signalling as expression of Fgf7 and Fgf10 are also downregulated.
112	11591823	To examine the potential role of fibroblast growth factor (FGF) signalling during cell differentiation, we used conditionally immortalised podocyte cells isolated from kidneys of Fgf2 mutant and wild-type mice.
113	11591823	Wild-type mouse podocyte cells upregulate FGF2 expression when differentiating in culture, as do maturing podocytes in vivo.
114	11591823	Molecular analysis of Fgf2 mutant mouse podocyte cells reveals a general disruption of FGF signalling as expression of Fgf7 and Fgf10 are also downregulated.