Ignet

Gene Information

Gene symbol: FLT1

Gene name: fms-related tyrosine kinase 1

HGNC ID: 3763

Synonyms: VEGFR1

Related Genes

#	Gene Symbol	Number of hits
1	KDR	1 hits
2	NRP1	1 hits
3	VEGFA	1 hits

Related Sentences

#	PMID	Sentence
1	9621286	The ability of VEGF to be chemotactic for monocytes and to increase the activity of collagenase and plasminogen activator may have implications for renal development and renal disease.
2	9621286	In humans, the cellular actions of VEGF depend on binding to two specific receptors: Flt-1 and KDR.
3	9621286	The aims of this study were: (1) to localize VEGF receptor proteins in human renal ontogenesis; (2) to quantify VEGF binding in human fetal and adult kidney; and (3) to dissect the binding into its two known components: the KDR and Flt-1 receptors.
4	9621286	The latter aim was achieved by competitive binding of VEGF and placenta growth factor-2, which only binds to Flt-1.
5	9621286	By double-label immunohistochemistry, VEGF receptor proteins were localized solely to endothelial cells of preglomerular vessels, glomeruli, and postglomerular vessels.
6	9621286	In developing glomeruli, VEGF receptor protein appeared as soon as endothelial cells were positive for von Willebrand factor.
7	9621286	Placenta growth factor-2 displaced VEGF binding in all renal structures by approximately 60%.
8	9621286	VEGF receptor proteins thus were found only in renal endothelial cells.
9	9621286	A coexpression of both VEGF binding sites could be shown, with Flt-1 demonstrating the most abundant VEGF receptor binding sites in the kidney.
10	9621286	The ability of VEGF to be chemotactic for monocytes and to increase the activity of collagenase and plasminogen activator may have implications for renal development and renal disease.
11	9621286	In humans, the cellular actions of VEGF depend on binding to two specific receptors: Flt-1 and KDR.
12	9621286	The aims of this study were: (1) to localize VEGF receptor proteins in human renal ontogenesis; (2) to quantify VEGF binding in human fetal and adult kidney; and (3) to dissect the binding into its two known components: the KDR and Flt-1 receptors.
13	9621286	The latter aim was achieved by competitive binding of VEGF and placenta growth factor-2, which only binds to Flt-1.
14	9621286	By double-label immunohistochemistry, VEGF receptor proteins were localized solely to endothelial cells of preglomerular vessels, glomeruli, and postglomerular vessels.
15	9621286	In developing glomeruli, VEGF receptor protein appeared as soon as endothelial cells were positive for von Willebrand factor.
16	9621286	Placenta growth factor-2 displaced VEGF binding in all renal structures by approximately 60%.
17	9621286	VEGF receptor proteins thus were found only in renal endothelial cells.
18	9621286	A coexpression of both VEGF binding sites could be shown, with Flt-1 demonstrating the most abundant VEGF receptor binding sites in the kidney.
19	10864579	Vascular endothelial growth factor (VEGF), a potent mitogen, is expressed in podocytes in the glomerulus, and VEGF receptors (flt-1, KDR, and neuropilin-1) are present on endothelial cells and other cell types.
20	10864579	In contrast, mesangial flt-1 and KDR receptor staining were both clearly seen in biopsy samples from proliferative renal diseases.
21	10864579	In conclusion, flt-1, KDR, and neuropilin-1 are present on cultured HMC, and VEGF(165) induces HMC proliferation.
22	10864579	In addition, the flt-1 and KDR receptors are expressed in the mesangium in mesangioproliferative disease.
23	10864579	Vascular endothelial growth factor (VEGF), a potent mitogen, is expressed in podocytes in the glomerulus, and VEGF receptors (flt-1, KDR, and neuropilin-1) are present on endothelial cells and other cell types.
24	10864579	In contrast, mesangial flt-1 and KDR receptor staining were both clearly seen in biopsy samples from proliferative renal diseases.
25	10864579	In conclusion, flt-1, KDR, and neuropilin-1 are present on cultured HMC, and VEGF(165) induces HMC proliferation.
26	10864579	In addition, the flt-1 and KDR receptors are expressed in the mesangium in mesangioproliferative disease.
27	10864579	Vascular endothelial growth factor (VEGF), a potent mitogen, is expressed in podocytes in the glomerulus, and VEGF receptors (flt-1, KDR, and neuropilin-1) are present on endothelial cells and other cell types.
28	10864579	In contrast, mesangial flt-1 and KDR receptor staining were both clearly seen in biopsy samples from proliferative renal diseases.
29	10864579	In conclusion, flt-1, KDR, and neuropilin-1 are present on cultured HMC, and VEGF(165) induces HMC proliferation.
30	10864579	In addition, the flt-1 and KDR receptors are expressed in the mesangium in mesangioproliferative disease.
31	10864579	Vascular endothelial growth factor (VEGF), a potent mitogen, is expressed in podocytes in the glomerulus, and VEGF receptors (flt-1, KDR, and neuropilin-1) are present on endothelial cells and other cell types.
32	10864579	In contrast, mesangial flt-1 and KDR receptor staining were both clearly seen in biopsy samples from proliferative renal diseases.
33	10864579	In conclusion, flt-1, KDR, and neuropilin-1 are present on cultured HMC, and VEGF(165) induces HMC proliferation.
34	10864579	In addition, the flt-1 and KDR receptors are expressed in the mesangium in mesangioproliferative disease.