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Gene Information
Gene symbol: HSPG2
Gene name: heparan sulfate proteoglycan 2
HGNC ID: 5273
Synonyms: perlecan, PRCAN
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BGN | 1 hits |
| 2 | COL1A1 | 1 hits |
| 3 | COL4A4 | 1 hits |
| 4 | DMD | 1 hits |
| 5 | GPC1 | 1 hits |
| 6 | IL7 | 1 hits |
| 7 | SDC1 | 1 hits |
| 8 | SDC4 | 1 hits |
| 9 | TGFB1 | 1 hits |
| 10 | UTRN | 1 hits |
| 11 | VCAN | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 9176840 | Mouse glomerular epithelial cells in culture with features of podocytes in vivo express aminopeptidase A and angiotensinogen but not other components of the renin-angiotensin system. |
| 2 | 9176840 | By indirect immunofluorescence, the cells were positive for cytokeratin, vimentin, desmin, and the ZO-1 protein, a component of the tight junction complex. |
| 3 | 9176840 | The mRNA expression of several components of the renin-angiotensin system was also examined, and some factors indirectly coupled to the renin-angiotensin system component angiotensin II in this podocytic culture by RT-PCR analysis. mRNA Expression for the angiotensin II degrading hydrolase aminopeptidase A and angiotensinogen was found, but this was not found for any other component of this system, such as renin, angiotensin-converting enzyme, or the angiotensin II receptors AT1a, AT1b, and AT2. |
| 4 | 9176840 | In addition, expression of the growth factors transforming growth factor-beta and interleukin-7, and the extracellular matrix components fibronectin, laminin B2, perlecan, and collagen IV alpha 1, was observed. |
| 5 | 9434070 | Syndecan-4, glypican-1 and biglycan were all expressed in normal glomeruli, whereas syndecan-1, perlecan and versican mRNAs were confined to the papillary area. |
| 6 | 9434070 | By hybridizing adjacent sections with a probe for the podocyte-specific PTPase GLEPP-1, the glomerular cells containing mRNA for syndecan-4 and glypican-1 could be identified as podocytes, whereas the cells expressing biglycan were identified as mesangial cells. |
| 7 | 9434070 | The constitutive expression of syndecan-4, glypican-1 and biglycan in glomerular cells points to a role for these polyanionic molecules in maintaining the integrity of the glomerular filtration barrier. |
| 8 | 10703664 | Because the major DG binding partners in the GBM (laminin, agrin, perlecan), and the intracellular dystrophin analogue utrophin are also present in glomeruli, it appears that podocytes adhere to the GBM via DG complexes, similar to muscle fibers in which actin is linked via dystrophin and DG to the extracellular matrix. |